ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Resolving the Quantitative-Qualitative Dilemma: A Critical Realist Approach [PDF]
, 2007 The philosophical issues underpinning the quantitative–qualitative divide in educational research are examined. Three types of argument which support a resolution are considered: pragmatism, false duality and warranty through triangulation. In addition a
Scott, David
core +1 more source
Oliver Wendell Holmes Jr.’s The Path of the Law – die Geburtsstunde des American Legal Realism [PDF]
, 2016 In diesem Artikel wird die Bedeutung des 1897 von Oliver Wendell Holmes Jr. veröffentlichten Aufsatzes The Path of the Law für die Entstehung des American legal realism sowie dessen Auswirkungen sowohl auf die juristische Ausbildung, als auch auf die ...
Kai Wörner
core +1 more source
Using critical realism in primary care research: an overview of methods
, 2020 Primary care research seeks to answer a wide variety of complex questions: how do we most effectively manage patients with multiple illnesses? When is the practice nurse the best-placed health professional to provide patient support?
E. Sturgiss, A. Clark
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Technician's Dream? The Critical Reception of 3-D Films in Britain [PDF]
, 2012 Recent debates about the role of 3-D within cinema (and other media) have contained the traces of a largely anti-stereoscopic agenda that can be traced back to critical responses to 3-D in the 1950s.
Johnston, Keith M.
core +1 more source
Critical realism in empirical research: employing techniques from grounded theory methodology
International Journal of Social Research Methodology, 2018 Whilst critical realism (CR) is becoming recognised as a significant meta-theory for the social sciences, there is little guidance on how to produce research which is consistent with its ontological and epistemological assumptions.
E. Hoddy
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Critical Realism versus Social Constructivism in International Relations [PDF]
The Journal of Philosophical Economics, 2011 This article discusses the methodological differences between the British school and the American school of international relations. It attempts to demonstrate that Susan Strange, representative of the British school, could be considered a critical ...
Roxana Bobulescu
doaj
Towards a Conceptualization of Sociomaterial Entanglement [PDF]
, 2015 In knowledge representation, socio-technical systems can be modeled as multiagent systems in which the local knowledge of each individual agent can be seen as a context. In this paper we propose formal ontologies as a means to
C Ghidini +15 more
core +1 more source