Results 131 to 140 of about 3,824,363 (314)
Reliability-Oriented Verification of Mission-Critical Software Systems
, 2009 Focus of thesis is on the effective reliability-driven verification of large critical software systems. Many challenges have to be addressed towards this aim.
RUSSO, STEFANO
core
A new scoring system for evaluation of multiple organ dysfunction syndrome in premature infants
, 2012 Background The Neonatal Multiple Organ Dysfunction (NEOMOD) scoring system is used to predict mortality in infants with multiple organ dysfunction syndrome (MODS). The NEOMOD scoring system was extended to include involvement of the microvascular system.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Contextualising Critical Design: Towards a Taxonomy of Critical Practice in Product Design [PDF]
, 2012 This study focuses on critical design practice. The research challenges the colloquial understanding of ‘critical design.’ It problematises, defines and reassesses the concept of ‘critical design’ situating it among other forms of critical design ...
Malpass, Matt, Malpass, M
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Functional Limit Theorems for Occupation Time Fluctuations of Branching Systems in the Cases of Large and Critical Dimensions [PDF]
Functional central limit theorem; Occupation time fluctuation; Branching particle system; Generalized Wiener process; Critical ...
Luis G. Gorostiza +2 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Critical Realism in Economics and Open-Systems Ontology: A Critique [PDF]
This paper examines the treatment of ontology offered by Critical Realism. Three main criticisms are made of the Critical Realist treatment of open systems.
Andrew Mearman
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Phase diagram of quantum critical system via local convertibility of ground state. [PDF]
Sci Rep, 2016 Liu SY +5 more
europepmc +1 more source