Results 141 to 150 of about 5,449,919 (359)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19.

Journal of the American Medical Association (JAMA), 2020
Coronavirus disease 2019 (COVID-19) appears to have significant extrapulmonary complications affecting multiple organ systems.1-3 Critically ill patients with COVID-19 often develop gastrointestinal complications during their hospital stay, including ...
M. El Moheb, L. Naar, M. Christensen, C. Kapoen, L. Maurer, M. Farhat, H. Kaafarani   +6 more
semanticscholar   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Balanced Crystalloids versus Saline in Critically Ill Adults

Journal Club AINS, 2018
BACKGROUND Both balanced crystalloids and saline are used for intravenous fluid administration in critically ill adults, but it is not known which results in better clinical outcomes.
M. Semler, W. Self, J. Wanderer, Jesse M. Ehrenfeld, Li Wang, Daniel W Byrne, J. Stollings, Avinash B. Kumar, C. Hughes, Antonio Hernandez, Oscar D. Guillamondegui, A. May, L. Weavind, J. Casey, E. Siew, A. Shaw, G. Bernard, T. Rice   +17 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Bradycardia resulting in cardiac arrest in a critically ill patient receiving dexmedetomidine

Trauma Case Reports, 2021
Dexmedetomidine is an alpha-2 agonist sedative and analgesic used in anesthesia practice, and it has become more prevalent in the critically ill patients requiring short-term mechanical ventilation.
Anoosh Bahraini, Oyshik Banerjee, Jin Ra
doaj  

Ill-posedness for one-dimensional wave maps at the critical regularity [PDF]

arXiv, 1998
We show that the wave map equation in $\R^{1+1}$ is in general ill-posed in the critical space $\dot H^{1/2}$, and the Besov space $\dot B^{1/2,1}_2$. The problem is attributed to the bad behaviour of the one-dimensional bilinear expression $D^{-1}(f Dg)$ in these spaces.
arxiv  

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Ill-posedness for the 2D viscous shallow water equations in the critical Besov spaces [PDF]

arXiv, 2017
In this paper, we prove that the 2D viscous shallow water equations is ill-posed in the critical Besov spaces $\B^{\frac2p-1}_{p,1}(\R^2)$ with $p>4$. Our proof mainly depends on the method introduced by the paper \cite{C-M-Z4}.
arxiv  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source