Results 181 to 190 of about 3,056 (192)

Modulation of proteoglycan receptor regulates RhoA/CRMP2 pathways and promotes axonal myelination

Neuroscience Letters, 2021
The function of the myelinating system is important because a defective myelin sheath results in various nervous disorders, including multiple sclerosis and peripheral neuropathies. The dorsal root entry zone (DREZ) is a transitional area between the central nervous system (CNS) and the peripheral nervous system (PNS) that is generated by two types of ...
Min, Yao, Jie, Fang, Wei, Tao, Gang, Feng, Mingyi, Wei, Yuhao, Gao, Wen, Xin, Yu, Li, Shiwei, Du   +8 more
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Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity

Journal of Molecular Neuroscience, 2019
Ketamine is widely used in infants and young children for anesthesia, and subanesthetic doses of ketamine make neurons form new protrusions and promote synapse formation. However, the precise pathological mechanisms remain to be elucidated. In this study, we demonstrated that ketamine administration significantly increased dendritic spine density and ...
Zhongqi Zhang, JiFeng Zhang, Jiong Li, Jiaqi Zhang, Li Chen, Yalan Li, Guoqing Guo   +6 more
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Tat-Collapsin Response Mediator Protein 2 (CRMP2) Increases the Survival of Neurons After NMDA Excitotoxity by Reducing the Cleavage of CRMP2

Neurochemical Research, 2013
Collapsin response mediator protein 2 (CRMP2) is a brain-specific multifunctional adaptor protein involved in neuronal polarity and axonal guidance. Our previous results showed CRMP2 may be involved in the hypoxic preconditioning and ischemic injury, but the mechanism was not clear.
Yanling, Yin, Yansong, Wang, Lumian, Chen, Song, Han, Li, Zhao, Yanlin, Luo, Junfa, Li   +6 more
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Inhibition of Ubc9-Induced CRMP2 SUMOylation Disrupts Glioblastoma Cell Proliferation

Journal of Molecular Neuroscience, 2019
Glioblastoma (GBM) is the most aggressive astrocytoma. Despite maximum treatment, the GBM usually recurs and the patient survival is poor. Thus, understanding the molecular mechanism of GBM progression will be meaningful to ameliorate this situation. In this study, collapsin response mediator protein 2 (CRMP2) and Ubc9 protein levels were evaluated in ...
Leilei Wang, Suzhen Ji
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Extracellular Application of CRMP2 Increases Cytoplasmic Calcium through NMDA Receptors

Neuroscience, 2018
Collapsin Response Mediator Protein 2 (CRMP2) is an intracellular protein involved in axon and dendrite growth and specification. In this study, CRMP2 was identified in a conditioned media derived from degenerated sciatic nerves (CM). On cultured rat hippocampal neurons, acute extracellular application of CM or partially purified recombinant CRMP2 ...
Castillo Soto, Francisca Cecilia, Martinez Rozas, Juan Carlos, Longart, Marines, García, Lisbeth, Hernández, Marianela, Carballo, Jeismar, Rojas, Héctor Gustavo, Matteo, Lorena Romina, Casique, Liliana, Escalona Hernández, José Leonardo, Rodríguez, Yuryanni, Rodríguez Durán, Jessica Jenireth, Hernández, Deyanell, Balbi, Domingo, Villegas, Raimundo   +14 more
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Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency

Neuroscience Research, 2019
Pyridoxal, an active form of vitamin B6, is known to inhibit formation of advanced glycation end-products and protect tissues from diabetic complications. Here we identified that pyridoxal is a required component for establishing Schwann cell myelination in our Schwann cell-dorsal root ganglion neuron co-culture system.
Fuminori Saitoh, Hiroko Hagiwara, Shuji Wakatsuki, Toshiyuki Araki   +3 more
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CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Science, 2018
A small molecule for stroke therapy Better therapies for motor impairments after stroke are greatly needed. In mice and nonhuman primates, Abe et al. found that edonerpic maleate enhanced synaptic plasticity and functional recovery after a traumatic insult to the brain (see the Perspective by Rumpel). This
Hiroki Abe, Susumu Jitsuki, Waki Nakajima, Yumi Murata, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya Takahashi   +15 more
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Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

Science Signaling, 2011
Repulsive guidance signaling triggers the collapse of neuronal growth cones through a mechanism involving oxidation and phosphorylation.
Akifumi, Morinaka, Mayumi, Yamada, Rurika, Itofusa, Yosuke, Funato, Yuta, Yoshimura, Fumio, Nakamura, Takeshi, Yoshimura, Kozo, Kaibuchi, Yoshio, Goshima, Mikio, Hoshino, Hiroyuki, Kamiguchi, Hiroaki, Miki   +11 more
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CRMP2 binding compound accelerates functional recovery from central nervous system damage

Folia Pharmacologica Japonica, 2022
Brain injury causes temporary or permanent impairment of brain function due to an accident or circulation disorders. Even after rehabilitation training, there are often persistent functional impairments. Recent advances in our understanding of the repair mechanisms of neural circuits after brain injury have led to the possibility that these mechanisms ...
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Úloha CRMP2 vo vývoji nervového systému.

2020
Regulation of axon guidance and pruning of inappropriate synapses is key to development of neural circuits. Secreted semaphorins are integral part of both processes. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating Semaphorin 3A (Sema3A) signaling, however, nothing is known about its role in the ...
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