Results 61 to 70 of about 9,113,589 (351)
Advanced Science, EarlyView.Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan +14 more
wiley +1 more source
The safety of vedolizumab for ulcerative colitis and Crohn's disease
Gut, 2016 Objective Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab.
J. Colombel +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang +11 more
wiley +1 more source
Enteral nutritional therapy for induction of remission in Crohn's disease.
Cochrane Database of Systematic Reviews, 2018 BACKGROUND Corticosteroids are often preferred over enteral nutrition (EN) as induction therapy for Crohn's disease (CD). Prior meta-analyses suggest that corticosteroids are superior to EN for induction of remission in CD.
N. Narula +5 more
semanticscholar +1 more source
Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation
Advanced Science, EarlyView.The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu +8 more
wiley +1 more source
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The bacteria that live within the human gut play crucial roles in regulating our primary metabolism, protecting us from pathogens, and developing our immune system.
Matthew T. Henke +5 more
semanticscholar +1 more source
Indian Journal of Medical Research, 2015 A 51 year old man presented to the department of Dermatology, Regional University Hospital of Málaga, Málaga, Spain, in May 2013, with remarkable lesions on the perineal, perianal and gluteal regions reaching the top of the lower limbs, which he had first noted two years earlier.
Pérez-Belmonte, Luis-Miguel +1 more
openaire +4 more sources