Results 71 to 80 of about 9,113,589 (351)

Management of Crohn's disease [PDF]

Archives of Disease in Childhood, 2015
Crohn's disease (CD) is rapidly increasing in children so an up to date knowledge of diagnosis, investigation and management is essential. Exclusive enteral nutrition is the first line treatment for active disease. The vast majority of children will need immunosuppressant treatment and around 20% will need treatment with biologics.
Jochen Kammermeier, Mark Furman, Mary-Anne Morris, Astor Rodrigues, Vikki Garrick, Richard K. Russell   +5 more
openaire   +4 more sources

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Inclusion of the Mesentery in Ileocolic Resection for Crohn’s Disease is Associated With Reduced Surgical Recurrence

Journal of Crohn's & Colitis, 2018
Background and Aims Inclusion of the mesentery during resection for colorectal cancer is associated with improved outcomes but has yet to be evaluated in Crohn’s disease.
C. Coffey, M. Kiernan, S. Sahebally, A. Jarrar, J. Burke, P. Kiely, B. Shen, D. Waldron, C. Peirce, M. Moloney, M. Skelly, P. Tibbitts, H. Hidayat, P. Faul, V. Healy, P. O'leary, L. Walsh, P. Dockery, R. O'Connell, Sean T. Martin, F. Shanahan, C. Fiocchi, C. Dunne   +22 more
semanticscholar   +1 more source

Pathophysiology of Crohn’s disease inflammation and recurrence

Biology Direct, 2020
Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influenced by a complex pathogenesis in which ...
L. Petagna, A. Antonelli, C. Ganini, V. Bellato, M. Campanelli, A. Divizia, C. Efrati, M. Franceschilli, A. Guida, S. Ingallinella, F. Montagnese, B. Sensi, L. Siragusa, Giuseppe S Sica   +13 more
semanticscholar   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

Journal of Immunology, 1996
In this study, we investigate whether human inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) is associated with altered lymphokine secretion profiles, as recently found in various animal models of chronic intestinal inflammation.
I. Fuss, M. Neurath, M. Neurath, M. Boirivant, J. Klein, C. Motte, S. Strong, C. Fiocchi, C. Fiocchi, W. Strober   +9 more
semanticscholar   +1 more source

Clinical and Economic Insights Into Surgery for Colonic Diverticular Perforation: A Long‐Term Observational Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
The sigmoid colon was the most common perforation site among patients with colonic diverticular perforation. The patients' conditions, length of hospital stay, and hospitalization cost were significantly worse in left‐sided colon diverticular perforation than in right‐sided colon diverticular perforation. The clinical characteristics differed according
Minoru Fujita, Noriaki Manabe, Munenori Takaoka, Masaharu Higashida, Hideo Matsumoto, Atsushi Urakami, Tomoki Yamatsuji, Tomio Ueno, Jiro Hata, Ken Haruma, Collaborators, Hisako Kubota, Jiro Hayashi, Masaki Matsubara, Takako Konishi, Emiko Bukeo, Tomohiro Tanikawa, Jun Nakamura, Mitsuhiko Suehiro, Maki Ayaki, Takahisa Murao, Kazuhiro Yoshida, Takashi Akiyama, Katsuya Kato, Hirofumi Kawamoto, Tomoari Kamada, Akiko Shiotani, Minoru Haisa, Yoshio Naomoto, Toshihiro Hirai   +29 more
wiley   +1 more source

Prognostic Value of Serum Insulin‐Like Growth Factor‐1 in Patients With Anal Fistula Treated by Incision‐Thread‐Drawing Surgery

Annals of Gastroenterological Surgery, EarlyView.
IGF‐1 levels above 174.9 ng/mL were associated with better wound healing and lower postoperative inflammation. Higher IGF‐1 levels correlated with improved anal function at 7 and 14 days post‐surgery. ABSTRACT Background Anal fistula is a chronic condition characterized by an abnormal tract between the anal canal and perianal skin, often leading to ...
Zhijun Wu, Xuexue Yin, Jing Li
wiley   +1 more source

Dietary Sugar and Crohn's Disease

Canadian Journal of Gastroenterology, 1988
Epidemiologically, Crohn's is a disease of modern Western civilization. The diet of the Western world is highly processed. Many surveys have shown that patients with Crohn's disease habitually eat more than the average amount of some processed foods ...
K.W. Heaton
doaj   +1 more source

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

PLoS ONE, 2008
The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies.
Petric Kuballa, Alan Huett, John D Rioux, Mark J Daly, Ramnik J Xavier   +4 more
doaj   +1 more source