Results 121 to 130 of about 9,364,795 (319)

DOP68 CD-TREAT diet induces remission and improves quality of life in an open label trial in children and adults with active Crohn’s Disease [PDF]

, 2022
Vaios Svolos, Richard Hansen, Robin Russell, Daniel R. Gaya, Swapan Paul, J Macdonald, Ben Nichols, Rodanthi Papadopoulou, Michael Logan, Shona Mckirdy, R. Gervais, Umer Zeeshan Ijaz, Simon Milling, Stephanie Shields, D C Wilson, Paul Henderson, S Din, Gwo‐Tzer Ho, Konstantinos Gerasimidis   +18 more
openalex   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Iron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel Disease [PDF]

, 2012
Background and Aims:We analyzed iron deficiency and the therapeutic response following intravenous ferric carboxymaltose in a large single-center inflammatory bowel disease (IBD) cohort.
Anker SD, Anker SD, Beate Löhr, Breymann C, Burkhard Göke, Carrier J, Chandler G, Cornelia Tillack, De Silva AD, Domenech E, Erichsen K, Erichsen K, Evstatiev R, Fabian Schnitzler, Fleming MD, Fleming RE, Florian Beigel, Ganz T, Gasche C, Gasche C, Julia Seiderer, Katsanos K, Kociol RD, Kulnigg S, Lomer MC, Maria Weidinger, Nemeth E, Nemeth E, Pizzi LT, Qunibi WY, Qunibi WY, Rüdiger P. Laubender, Schroder O, Semrin G, Simone Breiteneicher, Srigiridhar K, Stein J, Stephan Brand, Szczech LA, Tagboto S, Thomas Ochsenkühn, Van Wyck DB, Wells CW, Werner T, Wilson A, Wilson A   +45 more
core   +1 more source

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort

Angewandte Chemie International Edition, EarlyView.
Validating biomarkers of disease is necessary for clinical use. The Health Surveillance Panel (83 peptides from 57 proteins) was developed as a PRM assay and evaluated using the Stellar‐MS platform. The assay was validated with a large clinical cohort of inflammatory bowel disease patients alongside quality controls.
Qin Fu, Philip M. Remes, Jihyeon Lee, Cristina Jacob, Dalin Li, Manasa Vegesna, Koen Raedschelders, Ali Haghani, Emebet Mengesha, Philip Debbas, Esthelle Hoedt, Sandy Joung, Susan Cheng, Scott Peterman, Justyna Fert‐Bober, Gil Y. Melmed, Dermot P.B. McGovern, Christopher I. Murray, Jennifer E. Van Eyk   +18 more
wiley   +1 more source

Biomedical Applications of Nanozymes: An Enzymology Perspective

Angewandte Chemie International Edition, EarlyView.
With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov, Xiaohan Zhang, Ka‐Ying Wong, Jung Heon Lee, Juewen Liu   +4 more
wiley   +1 more source

Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective Despite the availability of biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit, Atul Singhal, Alan Kivitz, Edit Drescher, Yoshinori Taniguchi, Rosalía Martínez Pérez, Jaclyn Anderson, Ronilda D'Cunha, Weihan Zhao, Nicholas DeVogel, Julie Parmentier, Romy Christmann, Dilek Arikan, Howard Amital   +13 more
wiley   +1 more source

Crohn’s Disease: Is the Cold Chain Hypothesis Still Hot? [PDF]

, 2020
Jean‐Pierre Hugot, Anne Dumay, Frédérick Barreau, Ulrich Meinzer   +3 more
openalex   +1 more source

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, EarlyView.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Persistent Mesorectal Inflammatory Activity is Associated With Complications After Proctectomy in Crohn’s Disease [PDF]

, 2018
E. Joline de Groof, Jonathan H. M. van der Meer, Pieter J. Tanis, Jessica R. de Bruyn, Oddeke van Ruler, Geert D’Haens, Gijs R. van den Brink, Willem A. Bemelman, Manon E. Wildenberg, Christianne J. Buskens   +9 more
openalex   +1 more source

Creeping Fat in Crohn’s Disease: Innocuous or innocuum? [PDF]

, 2020
Peter Smith, C Bénézech
openalex   +1 more source