Results 121 to 130 of about 181,938 (338)

Measuring the Impact of the Substitution of Innovator Biologics With Biosimilars on Uptake and Costs Among Ontario Public Drug Benefit Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
In Ontario, biologics have historically represented a small proportion of public drug claims but a large proportion of spending. Biosimilars, lower cost alternatives to biologics, offer a potential solution to the rising spending on biologics. From March 2023 to January 2024, the Ontario Ministry of Health required public drug program beneficiaries on ...
Anita Iacono, Martin K. H. Ho, Joanna Yang, Tonya Campbell, William Wynne, Dana Shearer, Lene Andersen, Eric Majer, Shaleesa Ledlie, Mina Tadrous, Tara Gomes   +10 more
wiley   +1 more source

Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis

Acta Medica, 2014
Crohn’s disease is a chronic immune-mediated intestinal inflammation targeted against a yet incompletely defined subset of commensal gut microbiota and occurs on the background of a genetic predisposition under the influence of environmental factors ...
Lucia Hrnčířová, Jan Krejsek, Igor Šplíchal, Tomáš Hrnčíř   +3 more
doaj   +1 more source

Additional file 1: of Development and validation of the Crohnâ s disease patient-reported outcomes signs and symptoms (CD-PRO/SS) diary

, 2018
Development and validation of the Crohnâ s Disease Patient-reported Outcomes Signs and Symptoms (CD-PRO/SS) Diary. (DOCX 117 kb)
Higgins, Peter, Harding, Gale, Leidy, Nancy, DeBusk, Kendra, Patrick, Donald, Viswanathan, Hema, Fitzgerald, Kristina, Donelson, Sarah, Marcoli Cyrille, Ortmeier, Brian, Wilson, Hilary, Revicki, Dennis, Globe, Gary   +12 more
openaire   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3 [PDF]

, 2014
The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn’s disease compared to non-Jewish European ancestry populations and has a unique genetic history.
Abraham, Clara, Brant, Steven R., Burberry, Aaron, Cardinale, Christopher J., Cho, Judy H., Choi, Murim, Chowers, Yehuda, Desnick, Robert J., Evelyn Ng, Sok Meng, Ferguson, John, Gregersen, Peter K., Gusev, Alexander, Hakonarson, Hakon, Hui, Ken Y., Karban, Amir, Katz, Seymour, Lifton, Richard P., Mayer, Lloyd, Nuñez, Gabriel, Peter, Inga, Pe’er, Itsik, Silverberg, Mark S., Warner, Neil, Waterman, Matti, Zhang, Wei, Zhao, Hongyu   +25 more
core   +1 more source

Additional file 1: of Could Mycobacterium avium subspecies paratuberculosis cause Crohnâ s disease, ulcerative colitisâ Śand colorectal cancer?

, 2018
Descriptions and illustrations of the goblet cell hyperplasia lesion. The supplementary file discusses the descriptions and illustrations of the goblet cell hyperplasia lesion found in some of the references in the main text. (DOC 200 kb)
openaire   +1 more source

Additional file 1: of An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohnâ s disease

, 2015
CONSORT 2010 checklist. (DOC 217 kb)
Yoshimura, Naoki, Yokoyama, Yoko, Matsuoka, Katsuyoshi, Takahashi, Hiroki, Iwakiri, Ryuichi, Yamamoto, Takayuki, Nakagawa, Tomoo, Fukuchi, Takumi, Motoya, Satoshi, Kunisaki, Reiko, Kato, Shingo, Hirai, Fumihito, Yoh Ishiguro, Tanida, Satoshi, Hiraoka, Sakiko, Mitsuyama, Keiichi, Ishihara, Shunji, Tanaka, Shinji, Michiro Otaka, Osada, Taro, Kagaya, Takashi, Suzuki, Yasuo, Nakase, Hiroshi, Hanai, Hiroyuki, Watanabe, Kenji, Nobuhito Kashiwagi, Hibi, Toshifumi   +26 more
openaire   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn’s disease. A prospective comparison with conventional ultrasound, x ray studies, and ileocolonoscopy [PDF]

, 2004
F. Parente, S Greco, M Molteni, A Anderloni, G M Sampietro, P G Danelli, R Bianco, S Gallus, G Bianchi Porro   +8 more
openalex   +1 more source

Intestinal TB v/s Crohn’s disease –Mystery solved?

, 2021
Raghav Seth, Uma Debi, Pankaj Gupta, Lokesh Singh, Vishal Sharma, Harjeet Singh, Kaushal Kishor Prasad   +6 more
openalex   +1 more source