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Autopsy and Case Reports, 2015 Aretaeus of Cappadocia (1st century CE) described a young man with chronic and recurring abdominal distress possibly representing the first recorded instance of Crohn disease (CD).1-3 More evidence that this disease was extant for many years comes from ...
Stephen A. Geller +1 more
doaj +3 more sources
Indian Dermatology Online Journal, 2014 Crohn′s disease, first described in 1922, is characterized by segmental granulomatous inflammation of the intestinal tract and frequently involves the cutaneous tissues as well.
Padmavathy Lanka +4 more
doaj +3 more sources
Application of enterostomy in surgical treatment of Crohn disease [PDF]
Yixue xinzhi zazhi, 2023 Crohn disease is a chronic inflammatory disease characterized by segmental transmural inflammation of the gastrointestinal tract. The primary treatment for Crohn disease is medication, but as the disease progresses, complications such as obstruction ...
Song-Lin WAN, Zhao DING, Qun QIAN
doaj +1 more source
Crohn’s Disease of the Vulva: a Case Report [PDF]
Folia Medica, 2021 Crohn’s disease is a multi-systemic chronic inflammatory disease that can affect various organs besides the gastrointestinal tract such as joints, uvea, and the skin.
Kalliopi Kokkali +7 more
doaj +3 more sources
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
Journal of Clinical Investigation, 2014 Yael Haberman +23 more
openalex +2 more sources
Management of Crohn Disease: A Review.
Journal of the American Medical Association (JAMA), 2021 Importance Crohn disease, a chronic gastrointestinal inflammatory disease, is increasing in incidence and prevalence in many parts of the world. Uncontrolled inflammation leads to long-term complications, including fibrotic strictures, enteric fistulae ...
K. Cushing, P. Higgins
semanticscholar +1 more source
Upadacitinib Induction and Maintenance Therapy for Crohn's Disease.
New England Journal of Medicine, 2023 BACKGROUND Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is under investigation for the treatment of Crohn's disease. METHODS In two phase 3 induction trials (U-EXCEL and U-EXCEED), we randomly assigned patients with moderate-to-severe ...
E. Loftus +18 more
semanticscholar +1 more source