Results 11 to 20 of about 61,456 (351)
Autopsy and Case Reports, 2015 Aretaeus of Cappadocia (1st century CE) described a young man with chronic and recurring abdominal distress possibly representing the first recorded instance of Crohn disease (CD).1-3 More evidence that this disease was extant for many years comes from ...
Stephen A. Geller +1 more
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Crohn's disease or Crohn's diseases? [PDF]
Gut, 2003 Disease behaviour in Crohn’s disease is dynamic and not stable over time In their landmark paper of 1932, Crohn, Ginzburg, and Oppenheimer1 described “a disease of the terminal ileum, affecting mainly young adults and characterised by a subacute or chronic necrotising and cicratrising inflammation.
Arnott, IDR, Satsangi, J
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Medicine, 2003 Abstract Understanding the aetiology and pathogenesis of Crohn's disease remains a challenge, but it is clearly an interaction between the environment and a genetically susceptible individual. Multiple genes are being described, each contributing a small degree of susceptibility or protection, but the functional consequences of gene mutations are not ...
Gunnar Järnerot, Rune Sjödahl
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Research progress in the surgical treatment of anorectal stricture in Crohn disease [PDF]
Yixue xinzhi zazhi, 2023 Anorectal stricture is the most challenging complication of perianal Crohn disease, and it often has a severe negative impact on the patient's quality of life.
Jin-Rong LI +6 more
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Clostridium difficile infection in a patient with Crohn disease
Journal of the Formosan Medical Association, 2012 Crohn disease is a chronic inflammatory disorder, which is rare in pediatric patients. The definite etiology and mechanism to induce an acute exacerbation of Crohn disease remains mostly unknown.
Chien-Hui Hsu +2 more
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Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]
, 2006 The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon +4 more
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Opioid use is associated with decreased quality of life in patients with Crohn′s disease
The Saudi Journal of Gastroenterology, 2014 Background/Aims: Quality of life is an important consideration in the management of patients with Crohn′s disease. Previous studies suggest that Crohn′s disease patients using opioids may have decreased quality of life and increased risk of mortality ...
David Sanford +4 more
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Strategies and methods of medical therapy for refractory Crohn's disease [PDF]
Yixue xinzhi zazhi, 2022 Crohn's disease (CD) is an inflammatory bowel disease that can affect the entire digestive tract. Although new drugs have been introduced in recent years, there are still some patients who are unresponsive to various treatments.
Qiao ZHONG, A-Kang SHAO, Min CHEN
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Crohn's disease activity index and Vienna classification - Is it worthwhile to calculate before surgery? [PDF]
, 2006 Background: Crohn's disease (CD) patients with increased disease activity may reveal an increased risk for perioperative complications. The `Crohn's disease activity index' (CDAI) and the `Vienna classification' (VC) were developed for standardized ...
A. Beham +29 more
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The Lancet, 2012 Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth ...
William J. Sandborn, Daniel C. Baumgart
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