The Lancet, 2012 Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth ...
William J. Sandborn, Daniel C. Baumgart
openaire +3 more sources
Autophagy and Crohn's Disease [PDF]
Journal of Innate Immunity, 2013 Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of <i>NOD2</i>, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further ...
Hang Thi Thu Nguyen, - +3 more
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Journal of British Surgery, 1958 39 of 40 patients treated by the author up to 18 years with corticosteroids, antibiotics and psychotherapy replied to a postal questionnaire in 1969. For details, see table I. Previous reports of the relevance of emotional stress and personality to the etiology of Crohn’s disease are summarized together with types of provocative stress and personality ...
openaire +7 more sources
Unsupervised physics-informed neural network in reaction-diffusion biology models (Ulcerative colitis and Crohn's disease cases) A preliminary study [PDF]
arXiv, 2023 We propose to explore the potential of physics-informed neural networks (PINNs) in solving a class of partial differential equations (PDEs) used to model the propagation of chronic inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. An unsupervised approach was privileged during the deep neural network training.
arxiv
Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents. A systematic review of randomized controlled trials [PDF]
, 2014 Objective. Treatment with tumour necrosis factor antagonists (anti-TNF) has been recognized as a risk factor for tuberculosis (TB) reactivation. Our aim was to evaluate risk of TB reactivation in rheumatologic and non-rheumatologic diseases treated with ...
Armuzzi, Alessandro +9 more
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Small bowel carcinoma associated with Crohn`s disease: clinical review and case report [PDF]
, 2015 Crohn`s disease is a chronic relapsing and remitting inflammation of the bowel involving all its layers. A small bowel adenocarcinoma in Crohn`s disease is a rare entity. The literature about this disease is reviewed.
Gegova, A. T. +3 more
core +2 more sources
Ileal Adenocarcinoma with Liver Metastasis in Patient with Crohn\u27s Disease: A 9-Year Survival. [PDF]
, 2019 Small bowel adenocarcinoma is a rare but well-known complication of Crohn\u27s disease. The diagnosis of small bowel adenocarcinoma remains difficult since its presentation is highly variable and mimics active or obstructive Crohn\u27s disease.
Bruckner, H. +5 more
core +3 more sources
Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]
, 2006 The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon +4 more
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Cross-scale Attention Guided Multi-instance Learning for Crohn's Disease Diagnosis with Pathological Images [PDF]
arXiv, 2022 Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image driven" MIL algorithms which overlook the multi-scale (i.e. pyramidal) nature of WSIs.
arxiv
EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound - Part 1: Examination Techniques and Normal Findings (Short version) [PDF]
, 2016 ▼ In October 2014 the European Federation of Societies for Ultrasound in Medicine and Biology formed a Gastrointestinal Ultrasound (GIUS) task force group to promote the use of GIUS in a clinical setting.
Calabrese, E. +16 more
core +5 more sources