Results 271 to 280 of about 9,352,293 (347)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

[Histological and clinical overlap of hidradenitis suppurativa and Crohn disease under IL-17 inhibition]. [PDF]

Dermatologie (Heidelb)
Ocker L, Scheel C, Abu Rached N, Dörler M, Stücker M, Bechara F.   +5 more
europepmc   +1 more source

Treatment of Vedolizumab With Exclusive Enteral Nutrition in Adult Patients With Moderate to Severe Crohn's Disease (Crohn Exclusive Enteral Nutrition Study)

Jing Wang, Zhishun Tang, Jiao Li, Anning Yin, Yaqing Xu, Li‐Ping Zou, Haixia Ren, Jian Kang, Juan Su, Qian Zhou, Yang Wang, Wei Wang, Jing Zhang, Huipeng Wan, Ping An   +14 more
openalex   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Luteolin Inhibits NLRP3 Inflammasome Activation to Ameliorate DSS‐Induced Colitis by Regulating AMPK Signalling

Cell Proliferation, EarlyView.
Luteolin alleviates DSS‐induced ulcerative colitis in mice by targeting the NLRP3 inflammasome, as it shows no effect in NLRP3‐/‐ mice. It inhibits NLRP3 activation and IL‐1β secretion in macrophages by reducing ROS, mtROS and calcium levels via AMPK binding and signalling. Metabolomic changes suggest lipid metabolism involvement. Luteolin represents a
Lianxiang Luo, Fangfang Huang, Guixuan Fang, Yiming Sun, Liyan Deng, Yinglin Liao, Xinming Chen, Zhuosi Chen, Xinxun Lin   +8 more
wiley   +1 more source

Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods. [PDF]

Medicine (Baltimore)
Zhou W, Su P, Wang Y, Li Z, Li Z, Liu L.
europepmc   +1 more source

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Cutaneous non‐tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Cutaneous non‐tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24‐year‐period. Patients and Methods 73 patients with cutaneous NTM infections diagnosed at 17 different German University Hospitals from 2000 ...
Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez, Jonathan Jantsch, Mario Fabri, Esther von Stebut   +6 more
wiley   +1 more source

Guillain-Barré Syndrome in a Patient Receiving Anti-Tumor Necrosis Factor for Crohn Disease: Coincidence or Consequence? [PDF]

Am J Case Rep
Ferreira SDC, Vasconcelos JRO, Rezende REF, Aprile LRO, Troncon LEA.   +4 more
europepmc   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source