Nanomaterials and nanoparticles: Sources and toxicity [PDF]
Published in Biointerphases Vol. 2, issue 4 (2007) pages MR17 -
MR71, 2008 This review is written with the goal of informing public health concerns related to nanoscience, while raising awareness of nanomaterials toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to nanoparticles and dust from natural sources and human activities, the recent development of industry and ...
arxiv
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]
, 2012 Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Beigel, Florian +15 more
core +4 more sources
LPG: a four-groups probabilistic approach to leveraging pleiotropy in genome-wide association studies [PDF]
arXiv, 2017 To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding a light on the genetic architecture of complex diseases. Polygenicity of complex diseases, which refers to the phenomenon that a vast number of risk variants collectively contribute to the ...
arxiv
Efficacy of adalimumab as second-line therapy in a pediatric cohort of crohn’s disease patients who failed infliximab therapy: The Italian society of pediatric gastroenterology, hepatology, and nutrition experience [PDF]
, 2019 Background: Adalimumab (Ada) treatment is an available option for pediatric Crohn’s disease (CD) and the published experience as rescue therapy is limited.
Accomando S. +15 more
core +1 more source
EXACT-CT: EXplainable Analysis for Crohn's and Tuberculosis using CT [PDF]
arXivCrohn's disease and intestinal tuberculosis share many overlapping features such as clinical, radiological, endoscopic, and histological features - particularly granulomas, making it challenging to clinically differentiate them. Our research leverages 3D CTE scans, computer vision, and machine learning to improve this differentiation to avoid harmful ...
arxiv
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Immunotherapy of Crohn′s disease
Mediators of Inflammation, 1998 Although the initiating events of Crohn′s disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn′s disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this understanding, there has been a shift in
C. van Montfrans +2 more
openaire +5 more sources
Effects of Cromolyn on Inflammatory Bowel Disease of Childhood [PDF]
, 1978 Methods and Materials: Twelve children with CIBD (7 with CUC and 5 with Crohn\u27s) entered a trial with Cromolyn Sodium. The patient groups consisted mostly of those who had been treated with steroids over a 1-year period without suppression of disease ...
Piovanetti, Yvette
core +1 more source
Mycobacterium avium subsp paratuberculosis and Crohn´s disease [PDF]
, 2008 Mycobacterium avium subsp paratuberculosis (MAP) é o agente etilógico da doença de Johne, uma doença inflamatória intestinal que afecta o gado, bem como outras espécies de mamíferos. Existem evidências de que, em humanos, MAP também despoleta a doença de
Assunção, Amélia Sarmento
core +3 more sources
Arachidonic acid concentrations in patients with Crohn disease [PDF]
, 2000 Karen C. McCowen +2 more
openalex +1 more source