Results 21 to 30 of about 4,084 (213)

Efficacy and safety of different systemic drugs in the treatment of uremic pruritus among hemodialysis patients: a network meta-analysis based on randomized clinical trials [PDF]

Frontiers in Medicine
AimThis network meta-analysis was to analyze and rank the efficacy and safety of different systemic drugs in the treatment of uremic pruritus (UP) among hemodialysis patients.MethodPubMed, Embase, Cochrane Library, and Web of Science databases were ...
Xueqian Zhao, Haipeng Sun, Wei Li
doaj   +2 more sources

Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk

JOR Spine
Background Intervertebral disk (IVD) degeneration affects both humans and canines and is a major cause of low back pain (LBP). Mast cell (MC) and macrophage (MØ) infiltration has been identified in the pathogenesis of IVD degeneration (IVDD) in the human
Mary K. Heimann, Kelly Thompson, Gilian Gunsch, Shirley N. Tang, Brett Klamer, Kara Corps, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +8 more
doaj   +2 more sources

Release of Mast Cell Mediators from Cochlear Tissue Following Short Exposure to Compound 48/80 or Cisplatin, and Their Damage to Cochlear Structure [PDF]

Cells
The cochlea is susceptible to damage from ototoxic agents such as cisplatin, yet the mechanisms underlying cochlear injury remain incompletely understood.
Bin Zeng, Stefan Frischbutter, Sherezade Moñino-Romero, Jörg Scheffel, Frank Siebenhaar, Heidi Olze, Agnieszka J. Szczepek   +6 more
doaj   +2 more sources

The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis [PDF]

The Turkish Journal of Gastroenterology, 2023
Hanife Yurdakul Ertan , Günnur Özbakış Dengiz , Figen Baru, Yonca Yılmaz Ürün, Murat Can, Shemsu Umer Hussen, Yücel Üstündağ   +6 more
doaj   +2 more sources

Development and Evaluation of a Novel Polymer Drug Delivery System Using Cromolyn-Polyamides-Disulfide using Response Surface Design

Journal of Chemistry, 2022
The aim of this study was to employ nanoparticles as drug carriers. The research involved the design of cromolyn polyamide-disulfide nanocomposites to overcome the problem of frequent cromolyn doses and improve their properties.
Nadeen Mohammad Alkurdi, Samer Hasan Hussein-Al-Ali, Awad Albalwi, Mike Kh. Haddad, Yousef Aldalahmed, Dalia Khalil Ali   +5 more
doaj   +1 more source

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1 [PDF]

, 2013
PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Ahluwalia, A Mulla, AB Kay, Ajantha Sinniah, AM Lucas, Bernhard Ryffel, C Bandeira-Melo, C Dahl, CD John, CF Schwender, CF Schwender, CP Sung, CP Sung, DS Thomson, E Solito, E Solito, E Wells, EB Cook, Egle Solito, F D'Acquisto, FL Pearce, FN Gavins, FS Ng, G Folkerts, G Galatowicz, J Raud, JD Croxtall, JP Tarayre, JP Tarayre, JP Tarayre, JS Cox, JS Cox, JS Cox, JS Cox, K Kuriyama, L Jenkins, L Wang, M Corbel, M Perretti, M Shichijo, MK Church, NJ Goulding, PJ Barnes, R Sagi-Eisenberg, RH Grace, RJ Rintala, RM Viscardi, Rod J. Flower, RP Hayhoe, S Mattoli, S Murphy, S Pieretti, S Yazid, S Yazid, Samia Yazid, SH Lee, SH Peers, SI Wasserman, SilvaJR Lapa e, SK Bansal, SM Oliani, T Du, T Oka, T Radeau, TC Theoharides, TC Theoharides, TW Evans, Virginia Calder, WM Abraham, WM Abraham, Y Okayama, Y Yang, Y Zuo, YW Chung   +73 more
core   +5 more sources

CXCL10 Promotes Spinal Macrophage Recruitment via the JAK/STAT3 Pathway to Induce Pain in Experimental Autoimmune Prostatitis. [PDF]

Cell Prolif
The CXCL10/CXCR3 axis was involved in spinal macrophage infiltration through activating the JAK/STAT3 pathway. The prostate NGF/TrKA axis was involved in the neuroinflammation and pain in chronic prostatitis, and inhibition of NGF could attenuate pain response in chronic prostatitis, which provided novel therapeutic targets for pain treatment in ...
Chen L, Chen Z, Chen J, Du H, Chen X, Chen J, Wang H, Liang C.   +7 more
europepmc   +2 more sources

Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies

UroPrecision, Volume 1, Issue 4, Page 162-178, December 2023., 2023
Abstract Background As one of the most common diseases in urology, a large number of preclinical studies have been accumulated to explore the etiological mechanism and potential intervention of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
Yongfeng Lao, Xin Guan, Jian Wang, Yanan Bai, Zewen Li, Zhiping Wang, Zhilong Dong   +6 more
wiley   +1 more source

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

The Journal of Physiology, Volume 601, Issue 20, Page 4491-4538, 15 October 2023., 2023
Abstract figure legend Acute and chronic stress exert wide‐ranging effects across the gut–brain axis. In the case of acute stress, the enteric nervous system may be activated and gut contractility modified. This is associated with altered serotonin metabolism in the gastrointestinal tract as well as activation of the innate immune system and ...
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes, Paula Sanchez‐Diaz, Cassandra E. Gheorghe, Michael S. Goodson, Nancy Kelley‐Loughnane, Niall P. Hyland, John F. Cryan, Gerard Clarke   +9 more
wiley   +1 more source

Contemporary Concise Review 2022: Interstitial lung disease

Respirology, Volume 28, Issue 7, Page 627-635, July 2023., 2023
SUMMARY OF KEY POINTS Novel genetic associations for idiopathic pulmonary fibrosis (IPF) risk have been identified. Common genetic variants associated with IPF are also associated with chronic hypersensitivity pneumonitis. The characterization of underlying mechanisms, such as pathways involved in myofibroblast differentiation, may reveal targets for ...
David J. F. Smith, R. Gisli Jenkins
wiley   +1 more source