Results 61 to 70 of about 4,084 (213)

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Akin C, Akin C, Akin C, Alberto Orfao, Alvarez-Twose I, Arock M, Arredondo AR, Austen KF, Awad JA, Bodemer C, Boguslaw Nedoszytko, Bonadonna P, Butterfield JH, Castells MC, Cem Akin, Chin KW, Costa JJ, Daley T, Dean D. Metcalfe, Di Lorenzo G, Donker ML, Finkelman FD, Galli SJ, Garcia-Montero AC, Golden DB, González de Olano D, Hans-Peter Horny, Hogan AD, Horny HP, Johansson SG, Jordan JH, Joseph H. Butterfield, Karin Hartmann, Karl Sotlar, Knut Brockow, Lawrence B. Schwartz, Lieberman P, Luis Escribano, Maintz L, Mariana Castells, Massimo Triggiani, Melody C. Carter, Metcalfe DD, Metcalfe DD, Metcalfe DD, Michel Arock, Morel AM, Murphy S, Nedoszytko B, Peavy RD, Peter Valent, Philip Lieberman, Rivera J, Rudolf Valenta, Ruëff F, Samorapoompichit P, Sampson HA, Schwartz LB, Schwartz LB, Schwartz LB, Schwelberger HG, Serafin WE, Sonneck K, Sperr WR, Vadas P, Valent P, Valent P, Valent P, Valent P, Valent P, van der Donk EM, van Toorenenbergen AW, Webb LM, Wolfgang R. Sperr   +73 more
core   +1 more source

Congestion and Sinonasal Illness in Outer Space: A Study on the International Space Station

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Objectives This study aims to characterize quantitative data pertaining to sinonasal symptoms and their related medication use aboard the International Space Station (ISS). A secondary focus involves correlating these findings with mission parameters such as extravehicular activity (EVA) participation and mission duration.
Faizaan Khan, Koyal Ansingkar, Roshan Dongre, Zain Mehdi, Aatin K. Dhanda, Kayla Powell, Tariq Syed, Samuel E. Razmi, Isuru Somawardana, Jeffrey T. Vrabec, David Hilmers, Omar G. Ahmed, Masayoshi Takashima   +12 more
wiley   +1 more source

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease [PDF]

, 2017
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness, to ...
Arai Tetsuaki, Asada Takashi, Funayama Misato, Imamura Keiko, Inoue Haruhisa, Iwata Nobuhisa, Izumi Yuishin, Kaji Ryuji, Kawakatsu Shinobu, Kondo Takayuki, Miyake Michiyo, Nakagawa Masato, Ohta Akira, Tsukita Kayoko, Woltjen Knut, 新井 哲明   +15 more
core   +1 more source

Steroids in pediatric eosinophilic esophagitis [PDF]

, 2014
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids.
Contreras, Emily M., Gupta, Sandeep K.
core   +1 more source

The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review [PDF]

, 2004
Background The goal of much care in chronic childhood illness is to improve quality of life (QOL). However, surveys suggest QOL measures are not routinely included.
Clarke, S., Eiser, C.
core   +3 more sources

Meta‐Analysis: Evaluating Placebo Rates Across Outcomes in Eosinophilic Oesophagitis Randomised Controlled Trials

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 1, Page 32-43, January 2025.
This meta‐analysis evaluates the response to placebo across multiple outcome domains in eosinophilic oesophagitis trials. While > 40% of patients improve clinically on placebo (influenced by patient age and randomisation ratio), most patients do not improve histologically or endoscopically, highlighting the importance of objective disease assessment ...
Angelica Rivas, Newaz Shubidito Ahmed, Yuhong Yuan, Anila Qasim, David B. O'Gorman, Brian G. Feagan, Vipul Jairath, Albert J. Bredenoord, Evan S. Dellon, Christopher Ma   +9 more
wiley   +1 more source

Angiotensin II Induces Leukocyte–Endothelial Cell Interactions In Vivo Via AT1 and AT2 Receptor–Mediated P-Selectin Upregulation [PDF]

, 2000
Background—Angiotensin II (Ang II) plays a critical role in the development of vascular lesions in hypertension, atherosclerosis, and several renal diseases.
Esplugues Mota, Juan Vicente, Issekutz, Andrew C., Kubes, Paul, O'Connor Blasco, José Enrique, Piqueras Ruiz, Laura, Sanz Ferrando, María Jesús, Álvarez Ribelles, Ángeles   +6 more
core   +1 more source

The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]

, 2018
BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina, Graham, Delyth, Milligan, Graeme, Nicklin, Stuart A.   +3 more
core   +1 more source

Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis

International Forum of Allergy &Rhinology, Volume 14, Issue 3, Page 621-629, March 2024.
Abstract Objective To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflective total nasal symptom score (rTNSS ...
Daniel Gorelik, Jumah G. Ahmad, Samuel E. Razmi, Masayoshi Takashima, Yin Yiu, Apurva Thekdi, Murugappan Ramanathan Jr., Aatin K. Dhanda, Michael T. Yim, Omar G. Ahmed   +9 more
wiley   +1 more source