Results 91 to 100 of about 137,586 (311)

Genetic erosion in crops: concept, research results and challenges

, 2010
The loss of variation in crops clue to the modernization of agriculture has been described as genetic erosion The current paper discusses the different views that exist on the concept of genetic erosion in crops Genetic erosion of cultivated diversity is
Visser, L., Wouw, M.J., van de, Kik, C., van Treuren, R., Hintum, T.J.L., van, van Hintum, T.J.L., van de Wouw, M.J., Treuren, R., van   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The future of Sustainable Crop Protection Relies on increased diversity of cropping systems and landscapes

, 2018
The homogenization of agroecosystems through the loss of genetic diversity between and within crops, increased dependency on fewer crop protection products, and loss of seminatural features such as field boundaries threatens the sustainability of current
Mcmillan, V. E., Storkey, J., Bruce, T., Vanessa E. McMillan, Jonathan Storkey, Toby J.A. Bruce, Neve, P., Paul Neve   +7 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Data from: Crop rotational diversity enhances belowground communities and functions in an agroecosystem

, 2015
Biodiversity loss, an important consequence of agricultural intensification, can lead to reductions in agroecosystem functions and services. Increasing crop diversity through rotation may alleviate these negative consequences by restoring positive ...
M. D. McDaniel, Tiemann, L. K., Atkinson, E. E., McDaniel, M. D., Grandy, A. S., A. S. Grandy, E. Marin‐Spiotta, E. E. Atkinson, Grandy, A. Stuart, Marin-Spiotta, E., L. K. Tiemann   +10 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Contribution of Wheat Diversity to Total Factor Productivity in China

Journal of Agricultural and Resource Economics, 2008
The impact of wheat diversity on the productivity of wheat in China is examined using total factor productivity (TFP) and an instrumental variable approach.
Songqing Jin, Erika C.H. Meng, Ruifa Hu, Scott Rozelle, Jikun Huang   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A functional complementation of a cotton MIZU-KUSSEI1 homolog in the hydrotropism response of Arabidopsis thaliana roots

BMC Research Notes
Objective Plants control the direction of root growth toward moisture due to their sessile nature, a phenomenon known as hydrotropism. In Arabidopsis thaliana, the MIZU-KUSSEI1 (MIZ1) protein is essential for the hydrotropic response.
Su-Hwan Kwak, Wonkeun John Park
doaj   +1 more source

Interhousehold variability and its effects on seed circulation networks: a case study from northern Cameroon

Ecology and Society, 2016
We present a detailed ethnographic case study of sorghum seed acquisitions in a smallholder farming society in northern Cameroon. The effects of variability in household demographics and socioeconomic status on observed patterns of seed provisioning are ...
Jean Wencélius, Mathieu Thomas, Pierre Barbillon, Eric Garine   +3 more
doaj   +1 more source