Results 71 to 80 of about 137,586 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat

Frontiers in Plant Science
Diversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet, Isabelle Nadaud, Azahara C. Martin, Azahara C. Martin, Maria-Dolores Rey, Maria-Dolores Rey, Asma Ben Bouslah, Carus John-Bejai, Graham Moore, Pierre Sourdille   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamic transcriptomic features accompanying the onset of first flowering in roses

BMC Plant Biology
Background Onset time of the first flowering is pivotal for the reproductive success of perennial polycarpic plants especially in woody species, like roses.
Jing Wen, Jiu-Xia Zhao, Mi-Cai Zhong, Wei-Hua Cui, Shi-Zhao Zhou, Dan Wang, Shu Wang, Chun-Tao Wang, Xiao-Dong Jiang, Jin-Yong Hu   +9 more
doaj   +1 more source

Long-term crop rotation diversification enhances maize drought resistance through soil organic matter

Environmental Research Letters, 2021
Climate change adaptation requires building agricultural system resilience to warmer, drier climates. Increasing temporal plant diversity through crop rotation diversification increases yields of some crops under drought, but its potential to enhance ...
Leah L R Renwick, William Deen, Lucas Silva, Matthew E Gilbert, Toby Maxwell, Timothy M Bowles, Amélie C M Gaudin   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Crop diversity buffers the impact of droughts and high temperatures on food production

Environmental Research Letters, 2023
Weather extremes like droughts and heat waves are becoming increasingly frequent worldwide, with severe consequences for agricultural production and food security.
Delphine Renard, Lucie Mahaut, Frederik Noack   +2 more
doaj   +1 more source

Area And Diversity Of A Crop Reflects The Diversity Of Others

Journal of Agriculture and Environment, 2013
This study was carried out to relate the diversity of one crop in terms of number of landraces and farm area with the diversity of other crop. Information collected during baseline survey of in-situ global project (1999) on three crops namely rice, finger millet and sponge gourd in Jumla, Kaski and Bara of Nepal were used. Farm area of each variety and
Devendra Gauchan, Bimal Kumar Baniya, Madhusudan Prasad Upadhyay, Bal Krishna Joshi   +3 more
openaire   +2 more sources

Crop Type Exerts Greater Influence Upon Rhizosphere Phosphohydrolase Gene Abundance and Phylogenetic Diversity than Phosphorus Fertilization. [PDF]

, 2020
Rock phosphate is considered as an alternative form of phosphorus fertilizer in acidic, nutrient depleted soils of the Brazilian Cerrado. However, there is no information regarding the influence of phosphorus fertilizer sources in Cerrado soils upon ...
Neal, A. L., Gomes, E. A., Hughes, D. J., De Sousa, S. M., McLaren, T., Coelho, A. M., Campolino, M. L., De Paula Lana, U. G.   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source