Results 51 to 60 of about 103,332 (265)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Crop Diversity and Cropping Patterns of Comilla Region

Bangladesh Rice Journal, 2018
Comilla region is highly diverse in respect to topography, agro-ecology, land-use pattern and cropping systems. Planning of agricultural development largely depends on the reliable and comprehensive statistics of the existing cropping patterns, cropping intensity and crop diversity of a particular area, which will provide guideline to our policy makers,
SM Shahidullah, M Harunur Rashid, M Nasim, A Saha   +3 more
openaire   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Indigenous crop diversity maintained despite the introduction of major global crops in an African centre of agrobiodiversity

Plants, People, Planet, 2023
Societal Impact Statement The global success and expansion of a small pool of major crops, including rice, wheat and maize, risks homogenising global agriculture.
Chris Rampersad, Tesfu Geto, Tarekegn Samuel, Meseret Abebe, Marybel Soto Gomez, Samuel Pironon, Lucie Büchi, Jeremy Haggar, Jonathan Stocks, Philippa Ryan, Richard J. A. Buggs, Sebsebe Demissew, Paul Wilkin, Wendawek M. Abebe, James S. Borrell   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Realizing the potential of plant genetic resources: the use of phenomics for genebanks

Plants, People, Planet
Societal Impact Statement Genebanks contribute to global food security, directly influencing societal well‐being, by providing access to seed or genetic material that is more resilient to pests, diseases, and environmental stresses.
Kioumars Ghamkhar, Fiona R. Hay, Marleen Engbers, Hannes Dempewolf, Ulrich Schurr   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Compartment-specific assembly and genotype-associated differentiation of root microbiomes in saline–alkali-sensitive and -tolerant maize inbred lines

BMC Plant Biology
Background Plant-associated microorganisms can enhance crop growth and resilience to environmental stressors. Maize (Zea mays L.) selectively recruits beneficial microbes under saline–alkali stress; however, the interplay between maize genotypic ...
Run-Ze Sun, Xiao-Qiang Liu, Zhao-Lin Yang, Xiao-Gang Liu, Hong-Wu Wang, Xin Deng   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source