Results 61 to 70 of about 2,514,839 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A systematic representation of crop rotations. [PDF]

, 2008
Crop rotations are allocations by growers of crop types to specific fields through time. This paper aims at presenting (i) a systematic and rigorous mathematical representation of crops rotations; and (ii) a concise mathematical framework to model ...
Morris, J., Wood, G. A., Morris, Joe, Burgess, Paul J., Perry, J. N., Burgess, P. J., Castellazzi, M. S., Conrad, K. F.   +7 more
core   +1 more source

Realizing the potential of plant genetic resources: the use of phenomics for genebanks

Plants, People, Planet
Societal Impact Statement Genebanks contribute to global food security, directly influencing societal well‐being, by providing access to seed or genetic material that is more resilient to pests, diseases, and environmental stresses.
Kioumars Ghamkhar, Fiona R. Hay, Marleen Engbers, Hannes Dempewolf, Ulrich Schurr   +4 more
doaj   +1 more source

Adapting to the enemy: Rice yellow mottle virus (RYMV) evolutionary dynamics and durable resistance in African rice

Journal of Integrative Agriculture
Rice yellow mottle virus (RYMV) is one of the most destructive viral diseases affecting rice production in sub-Saharan Africa (SSA), where increasing demand and persistent yield gaps continue to compromise food security.
Isaac Tawiah, Richard Akromah, Alexander Wereko Kena, Charles Kodia Kwoseh, Shailesh Yadav, Kossi Lorimpo Adjah, Geoffrey Onaga, Benjamin Annor, Zenna Negussie, Tella Hamidatou Euridice, Scholastica Quaicoe, Nana Kofi Abaka Amoah   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Compartment-specific assembly and genotype-associated differentiation of root microbiomes in saline–alkali-sensitive and -tolerant maize inbred lines

BMC Plant Biology
Background Plant-associated microorganisms can enhance crop growth and resilience to environmental stressors. Maize (Zea mays L.) selectively recruits beneficial microbes under saline–alkali stress; however, the interplay between maize genotypic ...
Run-Ze Sun, Xiao-Qiang Liu, Zhao-Lin Yang, Xiao-Gang Liu, Hong-Wu Wang, Xin Deng   +5 more
doaj   +1 more source

Indigenous crop diversity maintained despite the introduction of major global crops in an African centre of agrobiodiversity

Plants, People, Planet, 2023
Societal Impact Statement The global success and expansion of a small pool of major crops, including rice, wheat and maize, risks homogenising global agriculture.
Chris Rampersad, Tesfu Geto, Tarekegn Samuel, Meseret Abebe, Marybel Soto Gomez, Samuel Pironon, Lucie Büchi, Jeremy Haggar, Jonathan Stocks, Philippa Ryan, Richard J. A. Buggs, Sebsebe Demissew, Paul Wilkin, Wendawek M. Abebe, James S. Borrell   +14 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source