Results 61 to 70 of about 503,448 (361)

Indigenous crop diversity maintained despite the introduction of major global crops in an African centre of agrobiodiversity

Plants, People, Planet, 2023
Societal Impact Statement The global success and expansion of a small pool of major crops, including rice, wheat and maize, risks homogenising global agriculture.
Chris Rampersad, Tesfu Geto, Tarekegn Samuel, Meseret Abebe, Marybel Soto Gomez, Samuel Pironon, Lucie Büchi, Jeremy Haggar, Jonathan Stocks, Philippa Ryan, Richard J. A. Buggs, Sebsebe Demissew, Paul Wilkin, Wendawek M. Abebe, James S. Borrell   +14 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Increasing Cultivar Diversity of Processing Tomato under Large Scale Organic Production in California [PDF]

, 2008
At an organic farm in California, higher plant diversity was hypothesized to enhance ecosystem functions and services. Plant diversity was manipulated temporally and spatially: mustard cover crop vs.
Barrios Masias, Felipe, Jackson, Louise
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Realizing the potential of plant genetic resources: the use of phenomics for genebanks

Plants, People, Planet
Societal Impact Statement Genebanks contribute to global food security, directly influencing societal well‐being, by providing access to seed or genetic material that is more resilient to pests, diseases, and environmental stresses.
Kioumars Ghamkhar, Fiona R. Hay, Marleen Engbers, Hannes Dempewolf, Ulrich Schurr   +4 more
doaj   +1 more source

Farmers' social identity and crop genetic diversity. The G x E x S model [PDF]

, 2012
A better knowledge of factors organizing crop genetic diversity in situ increases the efficiency of diversity analyses and conservation strategies, and requires collaboration between social and biological disciplines.
Coppens D'Eeckenbrugge, Géo, Leclerc, Christian   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat

Frontiers in Plant Science
Diversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet, Isabelle Nadaud, Azahara C. Martin, Azahara C. Martin, Maria-Dolores Rey, Maria-Dolores Rey, Asma Ben Bouslah, Carus John-Bejai, Graham Moore, Pierre Sourdille   +9 more
doaj   +1 more source

Long-term crop rotation diversification enhances maize drought resistance through soil organic matter

Environmental Research Letters, 2021
Climate change adaptation requires building agricultural system resilience to warmer, drier climates. Increasing temporal plant diversity through crop rotation diversification increases yields of some crops under drought, but its potential to enhance ...
Leah L R Renwick, William Deen, Lucas Silva, Matthew E Gilbert, Toby Maxwell, Timothy M Bowles, Amélie C M Gaudin   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source