Results 61 to 70 of about 103,332 (265)

Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat

open access: yesFrontiers in Plant Science
Diversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet   +9 more
doaj   +1 more source

Long-term crop rotation diversification enhances maize drought resistance through soil organic matter

open access: yesEnvironmental Research Letters, 2021
Climate change adaptation requires building agricultural system resilience to warmer, drier climates. Increasing temporal plant diversity through crop rotation diversification increases yields of some crops under drought, but its potential to enhance ...
Leah L R Renwick   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Dynamic transcriptomic features accompanying the onset of first flowering in roses

open access: yesBMC Plant Biology
Background Onset time of the first flowering is pivotal for the reproductive success of perennial polycarpic plants especially in woody species, like roses.
Jing Wen   +9 more
doaj   +1 more source

Crop diversity buffers the impact of droughts and high temperatures on food production

open access: yesEnvironmental Research Letters, 2023
Weather extremes like droughts and heat waves are becoming increasingly frequent worldwide, with severe consequences for agricultural production and food security.
Delphine Renard   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Crop diversification affects biological pest control [PDF]

open access: yesAgroznanje, 2013
Crop monocultures encourage the multiplication and spread of pest insects on massive and uniform crop. Numerous studies have evaluated the impact of plant diversification on pests and beneficial arthropods population dynamics in agricultural ecosystems ...
Marković Dimitrije
doaj   +1 more source

Area And Diversity Of A Crop Reflects The Diversity Of Others

open access: yesJournal of Agriculture and Environment, 2013
This study was carried out to relate the diversity of one crop in terms of number of landraces and farm area with the diversity of other crop. Information collected during baseline survey of in-situ global project (1999) on three crops namely rice, finger millet and sponge gourd in Jumla, Kaski and Bara of Nepal were used. Farm area of each variety and
Devendra Gauchan   +3 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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