Results 81 to 90 of about 503,448 (361)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Phylogeographic evidence of crop neo-diversity in Sorghum : [Abstract W101] [PDF]

open access: yes, 2009
We report here a study on sorghum, using a well characterized sample of diverse cultivars that we resequenced for portions of six genes possibly involved in grain quality variation.
Billot, Claire   +9 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Multiple scale analysis of genetic diversity in sorghum [PDF]

open access: yes, 2010
Crop species are characterised by their intimate association with human populations, their history and their practices and needs. In long domesticated crops, migration can have expanded gradually within continents and jumped between continents, shaping ...
Barnaud, Adeline   +6 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

From acidity to sweetness: a comprehensive review of carbon accumulation in grape berries

open access: yesMolecular Horticulture
Most of the carbon found in fruits at harvest is imported by the phloem. Imported carbon provide the material needed for the accumulation of sugars, organic acids, secondary compounds, in addition to the material needed for the synthesis of cell walls ...
Lizhen Lu, Serge Delrot, Zhenchang Liang
doaj   +1 more source

Outcrossing Levels and Fruit Quality in Single-Cultivar Blocks of a Multi-Cultivar Lychee (Litchi chinensis Sonn.) Orchard

open access: yesHorticulturae
Intraspecific diversity is often introduced in orchards to promote cross-pollination, which is essential for self-incompatible crops and beneficial for many self-compatible crops.
Stephen J. Trueman, Joel Nichols
doaj   +1 more source

ARCAD- Agropolis Resource Center for Crop Conservation, Adaptation and Diversity : a new open multi-function platform devoted to agrobiodiversity. Objectives and challenges [PDF]

open access: yes, 2009
ARCAD, short for Agropolis Resource Center for Crop Conservation, Adaptation and Diversity, is an initiative supported by Agropolis Fondation, the Region Languedoc Roussillon (France) and several French research institutions.
Labouisse, Jean-Pierre, Pham, Jean Louis
core  

Effect of Alley Cropping on Crops and Arthropod Diversity in Duzce, Turkey

open access: yesJournal of Agronomy and Crop Science, 2003
AbstractThe influence of alley cropping practices on trees, agricultural crops and arthropod diversity was studied in Duzce, Turkey. Six replications of three crops, maize (Zea mays L. var. rugosa), beans (Phaseolus vulgaris L.) and zucchini (Cucurbita pepo L.), were planted in the alleyways between rows of hybrid poplar [Populus euramericana (Dode ...
Akbulut, Süleyman   +2 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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