Results 81 to 90 of about 137,586 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Coccinellidae on native and introduced spruce in central Europe: conservation implications in urban areas

Frontiers in Ecology and Evolution
The abundance and species composition of adult ladybird communities (Coleoptera: Coccinellidae) were investigated on two congeneric trees, native Norway spruce (Picea abies) and the introduced blue spruce (Picea pungens), at four locations in Slovakia ...
Terézia Jauschová, Terézia Jauschová, Lenka Sarvašová, Peter Zach, Miroslav Saniga, Zdenka Martinková, Alois Honěk, Jiří Skuhrovec, Milada Holecová, Ján Kulfan   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

From acidity to sweetness: a comprehensive review of carbon accumulation in grape berries

Molecular Horticulture
Most of the carbon found in fruits at harvest is imported by the phloem. Imported carbon provide the material needed for the accumulation of sugars, organic acids, secondary compounds, in addition to the material needed for the synthesis of cell walls ...
Lizhen Lu, Serge Delrot, Zhenchang Liang
doaj   +1 more source

Outcrossing Levels and Fruit Quality in Single-Cultivar Blocks of a Multi-Cultivar Lychee (Litchi chinensis Sonn.) Orchard

Horticulturae
Intraspecific diversity is often introduced in orchards to promote cross-pollination, which is essential for self-incompatible crops and beneficial for many self-compatible crops.
Stephen J. Trueman, Joel Nichols
doaj   +1 more source

Effect of Alley Cropping on Crops and Arthropod Diversity in Duzce, Turkey

Journal of Agronomy and Crop Science, 2003
AbstractThe influence of alley cropping practices on trees, agricultural crops and arthropod diversity was studied in Duzce, Turkey. Six replications of three crops, maize (Zea mays L. var. rugosa), beans (Phaseolus vulgaris L.) and zucchini (Cucurbita pepo L.), were planted in the alleyways between rows of hybrid poplar [Populus euramericana (Dode ...
Akbulut, Süleyman, Keten, Akif, Stamps, William T.   +2 more
openaire   +1 more source

Uprooting Diversity? Peasant Farmers’ Market Engagements and the on-Farm Conservation of Crop Genetic Resources in the Guatemalan Highlands [PDF]

The long-term security of the global food supply is contingent upon the on-farm conservation of crop genetic diversity. Without it, food crops lack the ability to evolve in the face of new pests, emerging plant diseases, and changing environmental ...
S. Ryan Isakson
core  

Crop rotation phase has a greater impact on soil biology than crop rotation diversity

The effect of plant diversity on the belowground soil food web remains poorly understood. In this study the soil microbial community structure and biomass, and the abundance of microfauna, mesofauna, and macrofauna were assessed at three levels of crop ...
Thomas, Sion, Struijk, M., Leigh, Sam, Mortimer, Simon, Ashwood, F., Degani, Erika, Ashwood, Frank, Sizmur, Tom, Leigh, S. G., Whitmore, A. P., Thomas, S., Sizmur, T., Clark, Suzanne J., Mortimer, S. R., Bowen, Emma, Bowen, E., Struijk, Marijke, Degani, E., Whitmore, Andrew P., Clark, S. J.   +19 more
core   +1 more source