Results 81 to 90 of about 1,050,820 (318)

India’s water future to 2025-2050: Business-as-usual scenario and deviations [PDF]

Poverty / Mapping/ Water demand / Water supply / Population growth / Crop production / Crop yield / Groundwater irrigation / Food ...
Amarasinghe, Upali, Anand, B. K., Shah, Tushaar, Turral, Hugh   +3 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluation of drought-tolerant varieties based on root system architecture in cotton (Gossypium hirsutum L.)

BMC Plant Biology
Background Root system architecture (RSA) exhibits significant genetic variability and is closely associated with drought tolerance. However, the evaluation of drought-tolerant cotton cultivars based on RSA in the field conditions is still underexplored.
Congcong Guo, Lingxiao Zhu, Hongchun Sun, Qiucheng Han, Shijie Wang, Jijie Zhu, Yongjiang Zhang, Ke Zhang, Zhiying Bai, Anchang Li, Liantao Liu, Cundong Li   +11 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Characterization of low-N responses in maize (Zea mays L.) cultivars with contrasting nitrogen use efficiency in the North China Plain

Journal of Integrative Agriculture, 2019
Over-use of N fertilizer in crop production has resulted in a series of environmental problems in the North China Plain (NCP). Thus, improvement of nitrogen use efficiency (NUE) in summer maize has become an effective strategy for promoting sustainable ...
Xiang-ling LI, Li-guo GUO, Bao-yuan ZHOU, Xiang-ming TANG, Cong-cong CHEN, Lei ZHANG, Shao-yun ZHANG, Chong-feng LI, Kai XIAO, Wei-xin DONG, Bao-zhong YIN, Yue-chen ZHANG   +11 more
doaj   +1 more source

Impact of global warming on Chinese wheat productivity: [PDF]

"Climate change continues to have major impact on crop productivity all over the world. While many researchers have evaluated the possible impact of global warming on crop yields using mainly indirect crop simulation models, there are relatively few ...
Fang, Cheng, Rosegrant, Mark W., Wood, Stanley, You, Liangzhi   +3 more
core  

Tolerance to weed harrowing in spring barley genotypes [PDF]

, 2005
Controlling weeds in spring cereals grown under organic conditions is mostly done by post emergence weed harrowing, where spring tines of the weed harrow control weeds by uprooting and/or covering small weeds plants with soil.
Hansen, Preben Klarskov
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transcriptome analysis to identify genes related to programmed cell death resulted from manipulating of BnaFAH ortholog by CRISPR/Cas9 in Brassica napus

Scientific Reports
Fumarylacetoacetate hydrolase (FAH) catalyzes the final step of the tyrosine degradation pathway. In this study, we isolated and characterized two homologous BnaFAH genes in Brassica napus L.
Zhou Zhou, Tiantian Zhi, Jie Zou, Gang Chen   +3 more
doaj   +1 more source