Results 91 to 100 of about 17,266 (301)

A genetic analysis of the introgression process from cultivated lettuce (Lactuca sativa L.) to wild prickly lettuce (L. serriola L.)

, 2011
Many plant species can hybridise and produce fertile offspring. Hybridization between cultivated species and their wild relatives has raised concerns with regard to GM crops, as it constitutes a possible route along which the transgene could disperse ...
Uwimana, B.
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Human agricultural activities influence the flowering time of turnip in the Qinghai-Tibet Plateau

Plant Diversity
Tibetan turnip and oilseeds are the most important vegetables cultivated in the Qinghai-Tibet Plateau. Our field observations identified a dominant early-bolting phenotype at the vegetative growth stage in the Tibetan turnip, which was possibly due to ...
Yan Zheng, Landi Luo, Xieshengyang Li, Qian Chen, Ya Yang, Yuanwen Duan, Xiangxiang Kong, Yongping Yang   +7 more
doaj   +1 more source

Use made of wild legume relatives in breeding

, 2010
Presently vast genetic resources are available for improvement of the main crops used by humans and animals. The ex-situ collections safeguard those resources collected in the past, although not all collections are safe even today as far as personnel and
Upadhyaya, H.D., Pundir, R.P.S., Maesen, L.J.G., van der   +2 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

TetraRNA, a tetra-class machine learning model for deciphering the coding potential derivation of RNA world

Computational and Structural Biotechnology Journal
CncRNAs (coding and noncoding RNAs) are a class of bifunctional RNAs that that has both coding and noncoding biological activity. An increasing number of cncRNAs are being identified, prompting reassessment of our knowledge of RNA. However, most existing
Hanrui Bai, Jie Wang, Xiaoke Jiang, Zhen Guo, Wenjing Yang, Zitian Yang, Jing Li, Changning Liu   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Combatting environmental impacts and microbiological pollution risks in Potato cropping: Benefits of forage cultivation in a semi-arid region

Resources, Environment and Sustainability
Continuous potato cropping in semi-arid regions, which are vulnerable to erosion, reduces tuber yields and leads to a decline in soil quality. This research delves into the impact of forage cultivation on soil bacterial and archaeal communities and the ...
Xudong Sun, Yousif Abdelrahman Yousif Abdellah, Guangyan Wang, Huasen Wang, Jishao Jiang, Yu Zhang, Caspar C.C. Chater, Yongping Yang, Yuanwen Duan, Fuqiang Yu, Dong Liu   +10 more
doaj   +1 more source

PRO-WILD: Protect and Promote Crop Wild Relatives

This abstract outlines the principle and methods of the project PRO-WILD 'Protect and Promote Crop Wild Relatives', a EU Horizon funded project running from 2024 - 2029.
Gallmann, Nina, Le Gouis, Jacques, Kanner, Elsa, Willer, Helga   +3 more
openaire   +2 more sources