Results 71 to 80 of about 17,266 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Crop wild relatives: Reprinted from Geneflow 2006

, 2019
Crop wild relatives include crop ancestors as well as other species more or less closely related to crops. They are a critical source of genes for resistance to diseases, pests and stresses such as drought and extreme temperatures.
Crop Wild Relatives
core  

Introduction to crop wild relatives

, 2020
Food production has advanced from the original form where humans gathered food from the wild, to cultivation and selection of wild plants (landraces), and further to modern-day plant breeding of new varieties and cultivars with high quality, yields, and ...
Byrne, Patrick, Volk, Gayle M., Khoury, Colin K., Greene, Stephanie L.   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

DNA barcodes analyses provide insights into species delineation and possible cryptic species in Amentotaxus (Taxaceae)

BMC Plant Biology
Background Accurate species identification and species delineation is crucial for biodiversity conservation and biological research. DNA barcoding is an efficient tool for species identification and delineation, especially when using next-generation DNA ...
Dan Li, Zhi-Qiong Mo, Su Cheng, Jie Wang, Chao-Nan Fu, Michael Möller, Philip Thomas, Jianbin Yan, Lian-Ming Gao   +8 more
doaj   +1 more source

Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos

Plant Diversity
Rapid growth is an innovative trait of woody bamboos that has been widely studied. However, the genetic basis and evolution of this trait are poorly understood.
Ling Mao, Cen Guo, Liang-Zhong Niu, Yu-Jiao Wang, Guihua Jin, Yi-Zhou Yang, Ke-Cheng Qian, Yang Yang, Xuemei Zhang, Peng-Fei Ma, De-Zhu Li, Zhen-Hua Guo   +11 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Chromosome-level genome assembly of the tetraploid medicinal and natural dye plant Persicaria tinctoria

Scientific Data
Persicaria tinctoria (2n = 40) is an important traditional medicinal plant and natural dye source within the genus Persicaria. P. tinctoria has been utilized for its antibacterial, antiviral, anti-inflammatory, and tumor treatment properties ...
Qing Li, Hui Huang, Ruyan Fan, Qiannan Ye, Yanting Hu, Zhenzhen Wu, Chengjun Zhang, Yuhua Wang   +7 more
doaj   +1 more source

Resequencing of 284 genomes reveals evolutionary history and hotspot of genetic diversity of the giant bamboos

Plant Diversity
The Dendrocalamus giganteus complex comprises D. giganteus, D. calostachyus and D. sinicus, being the largest known, iconic bamboo species and is economically, ecologically and culturally significant in Southeast Asia, serving as a pillar of daily life ...
May Zin Win, Shuang-Xiu Xu, Shu-Yang Gao, Jing-Xia Liu, Zu-Chang Xu, Cen Guo, Yun-Long Liu, Peng-Fei Ma, De-Zhu Li   +8 more
doaj   +1 more source

Preserving the wildness of crop wild relatives [PDF]

Agroecology and Sustainable Food Systems, 2021
openaire   +1 more source