Results 71 to 80 of about 14,077 (260)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Combatting environmental impacts and microbiological pollution risks in Potato cropping: Benefits of forage cultivation in a semi-arid region

Resources, Environment and Sustainability
Continuous potato cropping in semi-arid regions, which are vulnerable to erosion, reduces tuber yields and leads to a decline in soil quality. This research delves into the impact of forage cultivation on soil bacterial and archaeal communities and the ...
Xudong Sun, Yousif Abdelrahman Yousif Abdellah, Guangyan Wang, Huasen Wang, Jishao Jiang, Yu Zhang, Caspar C.C. Chater, Yongping Yang, Yuanwen Duan, Fuqiang Yu, Dong Liu   +10 more
doaj   +1 more source

CROP WILD RELATIVES OF THE AKTOBE FRORAL DISTRICT

Труды по прикладной ботанике, генетике и селекции, 2018
For the first time crop wild relatives have been found and recorded in the Aktobe floral district. They have been catalogued in a summary of crop wild relatives which includes data on 412 species.
S. A. Aipeisova
doaj   +1 more source

PRO-WILD: Protect and Promote Crop Wild Relatives

This abstract outlines the principle and methods of the project PRO-WILD 'Protect and Promote Crop Wild Relatives', a EU Horizon funded project running from 2024 - 2029.
Gallmann, Nina, Le Gouis, Jacques, Kanner, Elsa, Willer, Helga   +3 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A revised classification of Dryopteridaceae based on plastome phylogenomics and morphological evidence, with the description of a new genus, Pseudarachniodes

Plant Diversity
Dryopteridaceae are the largest fern family and include nearly 20% of extant fern diversity, with 24 currently recognized genera. Recognition and delineation of genera within this family have varied greatly.
Zheng-Yu Zuo, Germinal Rouhan, Shi-Yong Dong, Hong-Mei Liu, Xin-Yu Du, Li-Bing Zhang, Jin-Mei Lu   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Multifaceted plant diversity patterns across the Himalaya: Status and outlook

Plant Diversity
Mountains serve as exceptional natural laboratories for studying biodiversity due to their heterogeneous landforms and climatic zones. The Himalaya, a global biodiversity hotspot, hosts rich endemic flora, supports vital ecosystem functions, and offers a
Mustaqeem Ahmad, Ya-Huang Luo, Sonia Rathee, Robert A. Spicer, Jian Zhang, Moses C. Wambulwa, Guang-Fu Zhu, Marc W. Cadotte, Zeng-Yuan Wu, Shujaul Mulk Khan, Debabrata Maity, De-Zhu Li, Jie Liu   +12 more
doaj   +1 more source

CWRML: representing crop wild relative conservation and use data in XML

BMC Bioinformatics, 2008
Background Crop wild relatives are wild species that are closely related to crops. They are valuable as potential gene donors for crop improvement and may help to ensure food security for the future.
Ford-Lloyd Brian V, Iriondo Jose M, Kell Shelagh P, Moore Jonathan D, Maxted Nigel   +4 more
doaj   +1 more source