Results 51 to 60 of about 14,077 (260)

Comparative metabolomics of two nettle species unveils distinct high-altitude adaptation mechanisms on the Tibetan Plateau

BMC Plant Biology
Background The extreme high-altitude conditions of the Tibetan Plateau, characterized by intense solar radiation, low temperatures, and reduced oxygen levels, poses significant challenges to plant survival.
Li-Juan Deng, Yin-Lei Li, Feng-Ying Wang, Xiang-Qian Sun, Richard I. Milne, Jie Liu, Zeng-Yuan Wu   +6 more
doaj   +1 more source

A robust phylogenomic framework supports a revised intrafamilial classification of Urticaceae

Plant Diversity
Over the past decade, phylogenomics has significantly enhanced our understanding of relationships among numerous angiosperm lineages. However, comprehensive phylogenetic studies combining broad sampling of both genomic sequences and taxa within the ...
Xiao-Gang Fu, Jie Liu, Richard I. Milne, Alex K. Monro, Shui-Yin Liu, Qin Tian, Gregory W. Stull, Amos Kipkoech, Ting-Shuang Yi, De-Zhu Li, Zeng-Yuan Wu   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

DNA barcodes analyses provide insights into species delineation and possible cryptic species in Amentotaxus (Taxaceae)

BMC Plant Biology
Background Accurate species identification and species delineation is crucial for biodiversity conservation and biological research. DNA barcoding is an efficient tool for species identification and delineation, especially when using next-generation DNA ...
Dan Li, Zhi-Qiong Mo, Su Cheng, Jie Wang, Chao-Nan Fu, Michael Möller, Philip Thomas, Jianbin Yan, Lian-Ming Gao   +8 more
doaj   +1 more source

Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos

Plant Diversity
Rapid growth is an innovative trait of woody bamboos that has been widely studied. However, the genetic basis and evolution of this trait are poorly understood.
Ling Mao, Cen Guo, Liang-Zhong Niu, Yu-Jiao Wang, Guihua Jin, Yi-Zhou Yang, Ke-Cheng Qian, Yang Yang, Xuemei Zhang, Peng-Fei Ma, De-Zhu Li, Zhen-Hua Guo   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Chromosome-level genome assembly of the tetraploid medicinal and natural dye plant Persicaria tinctoria

Scientific Data
Persicaria tinctoria (2n = 40) is an important traditional medicinal plant and natural dye source within the genus Persicaria. P. tinctoria has been utilized for its antibacterial, antiviral, anti-inflammatory, and tumor treatment properties ...
Qing Li, Hui Huang, Ruyan Fan, Qiannan Ye, Yanting Hu, Zhenzhen Wu, Chengjun Zhang, Yuhua Wang   +7 more
doaj   +1 more source

Resequencing of 284 genomes reveals evolutionary history and hotspot of genetic diversity of the giant bamboos

Plant Diversity
The Dendrocalamus giganteus complex comprises D. giganteus, D. calostachyus and D. sinicus, being the largest known, iconic bamboo species and is economically, ecologically and culturally significant in Southeast Asia, serving as a pillar of daily life ...
May Zin Win, Shuang-Xiu Xu, Shu-Yang Gao, Jing-Xia Liu, Zu-Chang Xu, Cen Guo, Yun-Long Liu, Peng-Fei Ma, De-Zhu Li   +8 more
doaj   +1 more source

Preserving the wildness of crop wild relatives [PDF]

Agroecology and Sustainable Food Systems, 2021
openaire   +1 more source