Results 101 to 110 of about 665,613 (290)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Clinical Outcomes of Repeated Corneal Crosslinking for Progressive Keratoconus After Failure of Primary Procedure; Safety and Efficacy at 12-Month Follow-Up

Ophthalmology and Therapy
Introduction This study aims to evaluate the efficacy and safety of repeated corneal cross-linking (CXL) in patients with progressive keratoconus who have undergone an unsuccessful primary epithelium-off (epi-off) CXL procedure. Additionally, it compares
Mohamed Elalfy, Eleftherios Chatzimichail, Kareem Mahgoub, Aida Hajjar-Sese, Hasan Naveed, Georgios D. Panos, Khaled Abdelhamid, Frank Blaser, Artemis Matsou, Zisis Gatzioufas   +9 more
doaj   +1 more source

Dynamic-Cross-Linked, Regulated, and Controllable Mineralization Degree and Morphology of Collagen Biomineralization

Journal of Functional Biomaterials
The cross-linking process of collagen is one of the more important ways to improve the mineralization ability of collagen. However, the regulatory effect of dynamic cross-linking on biomineralization in vitro remains unclear.
Ziyao Geng, Fan Xu, Ying Liu, Aike Qiao, Tianming Du   +4 more
doaj   +1 more source

A Scaling Theory of the Competition between Interdiffusion and Cross-Linking at Polymer Interfaces

, 2002
We study theoretically situations where competition arises between an interdiffusion process and a cross-linking chemical reaction at interfaces between pieces of the same polymer material. An example of such a situation is observable in the formation of
Aradian, Achod, de Gennes, Pierre-Gilles, Raphael, Elie   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

In-situ cross linking of polyvinyl alcohol [PDF]

, 1981
A method of producing a crosslinked polyvinyl alcohol structure, such as a battery separator membrane or electrode envelope is described. An aqueous solution of a film-forming polyvinyl alcohol is admixed with an aldehyde crosslinking agent a basic pH to
Hsu, L. C., Philipp, W. H., Sheibley, D. W.   +2 more
core   +1 more source

Cross-linking patterns and their images in swollen and deformed gels

, 2015
Using the theory of elasticity of polymer gels we show that large-scale cross-link density patterns written into the structure of the network in the melt state, can be revealed upon swelling by monitoring the monomer density patterns.
Panyukov, Sergey, Rabin, Yitzhak
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Extended depth of focus lens implantation after radial keratotomy [Letter]

Clinical Ophthalmology, 2019
Arjun SrirampurDepartment of Cornea, Cataract and Refractive Surgery, Anand Eye Institute, Hyderabad 500007, IndiaCorrespondence: Arjun SrirampurAnand Eye Institute, Habsiguda, Hyderabad 500007, IndiaTel +91 998 922 9832Fax +91 402 715 1999Email ...
Srirampur A
doaj  

Double contact lens-assisted corneal cross-linking in ultrathin corneas with keratoconus

Saudi Journal for Health Sciences, 2018
Aims: This study aimed to evaluate the safety and effectiveness of double contact lens-assisted corneal cross-linking (CXL) in keratoconus patients with very thin corneas.
Abdulrahman M Alamri
doaj   +1 more source