Results 71 to 80 of about 665,613 (290)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]

, 2012
G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder, Goddard, William A., III, Grunbeck, Amy, Huber, Thomas, Sakmar, Thomas P., Trzaskowski, Bartosz   +5 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN

Oftalʹmologiâ, 2017
Keratoconus is a progressive degenerative corneal disease. It causes a disruption in the structure and organization of the corneal collagen matrix and leads to its thinning and protrusion.
E. Y. Markova, S. V. Kostenev, A. G. Grigor’eva, E. A. Perfileva   +3 more
doaj   +1 more source

Thermal degradation of Cross-Linked Polyisoprene and Polychloroprene [PDF]

, 2000
Polyisoprene and polychloroprene have been cross-linked either in solution or in solid state using free radical initiators. In the comparable experimental conditions higher cross-linking density was observed in the solid state process. Independent of the
Dick, Caroline, Jiang, David D., Levchik, Galina F, Levchik, Sergei V, Liggat, John J, Snape, C.E., Wilkie, Charles A.   +6 more
core   +1 more source

Solution-processed bilayer photovoltaic devices with nematic liquid crystals [PDF]

, 2013
The cross-linking of polymerisable liquid crystalline semiconductors is a promising approach to solution-processable, multilayer, organic photovoltaics. Here we demonstrate an organic bilayer photovoltaic with an insoluble electron-donating layer formed ...
AlKhalifah, Manea S., Kelly, Stephen M., Kitney, Stuart P., Lei, Chunhong, Myers, Steven A., O’Neill, Mary   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Refractive meridional corneal collagen cross-linking: a new modified technique for treatment of astigmatism

Delta Journal of Ophthalmology, 2015
Purpose The aim of the study was to evaluate the efficacy and safety of using corneal collagen cross-linking as a refractive procedure to correct corneal astigmatism. Setting This study was conducted in Sohag University Hospital (Egypt). Design This is a
Mohamed Iqbal Hafez
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Structure and kinetics of chemically cross-linked protein gels from small-angle X-ray scattering

, 2014
Glutaraldehyde (GA) reacts with amino groups in proteins, forming intermolecular cross-links that, at sufficiently high protein concentration, can transform a protein solution into a gel.
Halle, Bertil, Kaieda, Shuji, Plivelic, Tomás S.   +2 more
core   +1 more source