Results 51 to 60 of about 5,480 (194)

New library of aminosulfonyl-tagged Hoveyda–Grubbs type complexes: Synthesis, kinetic studies and activity in olefin metathesis transformations

Beilstein Journal of Organic Chemistry, 2010
Seven novel Hoveyda–Grubbs precatalysts bearing an aminosulfonyl function are reported. Kinetic studies indicate an activity enhancement compared to Hoveyda’s precatalyst.
Etienne Borré, Frederic Caijo, Christophe Crévisy, Marc Mauduit   +3 more
doaj   +1 more source

A Short and Efficient Total Synthesis of Ficuseptamines A and B

Molecules, 2018
A rapid and efficient total synthesis of ficuseptamines A and B by a cross metathesis strategy is described.
Hani Mutlak A. Hassan
doaj   +1 more source

Unlocking Catalyst Activation as a Critical Bottleneck in Cross‐Coupling Reactions: Room‐Temperature Couplings of Weak Nucleophiles Enabled by [Pd(1‐MeNAP)TFA]2 Precatalysts

Angewandte Chemie International Edition, EarlyView.
In many Pd‐catalyzed cross‐couplings, catalyst performance has been found to be limited by catalyst activation. Methylnaphthyl (MeNAP) palladium trifluoroacetate dimers are presented as easy‐to‐store and easy‐to‐handle precursors, which rapidly activate under reaction conditions, even when only weakly coordinating, non‐reducing nucleophiles are present.
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Ene–yne cross-metathesis with ruthenium carbene catalysts

Beilstein Journal of Organic Chemistry, 2011
Conjugated 1,3-dienes are important building blocks in organic and polymer chemistry. Enyne metathesis is a powerful catalytic reaction to access such structural domains.
Cédric Fischmeister, Christian Bruneau
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Nitro-Grela-type complexes containing iodides – robust and selective catalysts for olefin metathesis under challenging conditions

Beilstein Journal of Organic Chemistry, 2015
Iodide-containing nitro-Grela-type catalysts have been synthesized and applied to ring closing metathesis (RCM) and cross metathesis (CM) reactions. These new catalysts have exhibited improved efficiency in the transformation of sterically, non-demanding
Andrzej Tracz, Mateusz Matczak, Katarzyna Urbaniak, Krzysztof Skowerski   +3 more
doaj   +1 more source

Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine

Beilstein Journal of Organic Chemistry, 2014
(2S,3S)-3-Hydroxyleucine can be found in an increasing number of bioactive natural products. Within the context of our work regarding the total synthesis of muraymycin nucleoside antibiotics, we have developed a synthetic approach towards (2S,3S)-3 ...
Oliver Ries, Martin Büschleb, Markus Granitzka, Dietmar Stalke, Christian Ducho   +4 more
doaj   +1 more source

Concise Synthesis of Broussonone A

Molecules, 2015
A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a ...
Hyeju Jo, Minho Choi, Mayavan Viji, Young Hee Lee, Young-Shin Kwak, Kiho Lee, Nam Song Choi, Yeon-Ju Lee, Heesoon Lee, Jin Tae Hong, Mi Kyeong Lee, Jae-Kyung Jung   +11 more
doaj   +1 more source

α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA

Beilstein Journal of Organic Chemistry, 2019
An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro derivative is obtained through a cross metathesis reaction between a suitable terminal ...
Shital K. Chattopadhyay, Subhankar Ghosh, Sarita Sarkar, Kakali Bhadra   +3 more
doaj   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source