Results 101 to 110 of about 709,594 (295)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
3-crossed module structure in the five-dimensional topological axion electrodynamics
Journal of High Energy PhysicsIn this paper, we investigate the higher-group symmetry structure of a five-dimensional topological theory, which is described by a 3-crossed module.
Masaki Fukuda, Tommy Shu, Ryo Yokokura
doaj +1 more source
Dynamics of a lattice 2-group gauge theory model
Journal of High Energy Physics, 2021 We study a simple lattice model with local symmetry, whose construction is based on a crossed module of finite groups. Its dynamical degrees of freedom are associated both to links and faces of a four-dimensional lattice.
A. Bochniak +3 more
doaj +1 more source
Internal crossed modules and Peiffer Condition [PDF]
Theory and Applications of Categories, 2010 Summary: In this paper we show that in a homological category in the sense of F. Borceux and D. Bourn, the notion of an internal precrossed module corresponding to a star-multiplicative graph, in the sense of G. Janelidze, can be obtained by directly internalizing the usual axioms of a crossed module, via equivariance.
S. Mantovani, G. Metere
openaire +3 more sources
The homotopy categorical crossed module of a CW-complex [PDF]
, 2007 Crossed modules have longstanding uses in homotopy theory and the cohomology of groups. The corresponding notion in the setting of categorical groups, that is, categorical crosses modules, allowed the development of a low-dimensional categorical group ...
Garzón, A.R. +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Abelian Extensions of Modified λ-Differential Left-Symmetric Algebras and Crossed Modules
AxiomsIn this paper, we define a cohomology theory of a modified λ-differential left-symmetric algebra. Moreover, we introduce the notion of modified λ-differential left-symmetric 2-algebras, which is the categorization of a modified λ-differential left ...
Fuyang Zhu, Taijie You, Wen Teng
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Braided equivariant crossed modules and cohomology of Γ-modules
Indian Journal of Pure and Applied Mathematics, 2014 If $Γ$ is a group, then braided $Γ$-crossed modules are classified by braided strict $Γ$-graded categorial groups. The Schreier theory obtained for $Γ$-module extensions of the type of an abelian $Γ$-crossed module is a generalization of the theory of $Γ$-module extensions.
Quang, N. T. +2 more
openaire +2 more sources