Results 141 to 150 of about 6,655,728 (369)

Biparental inbreeding depression, genetic relatedness and progeny vigor in a wind-pollinated treeline species in Argentina [PDF]

open access: yes, 2009
Spatially restricted gene flow and resulting spatial genetic structure are generally considered as being the primary controlling factors in the dynamics of biparental inbreeding depression in a wide range of plant species.
Cocucci, Andrea Aristides   +7 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A cytological demonstration of "genetic" crossing-over [PDF]

open access: yesProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1930
A stage in meiosis where the paired chromosomes form loops, coming together at points distributed at random along their length, was first described by Rückert (1892) inPristiurus. These points we now recognise in suitable material as exchanges of partner amongst the four pairing half-chromosomes.
openaire   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

The effect of temperature on seed quality and quantity in crosses between European (Populus tremula) and hybrid aspens (P. tremula x P. tremuloides)

open access: yesSilva Fennica, 2012
Hybrid aspen (Populus tremula L. Populus tremuloides Michx.) plantations are expanding in Fennoscandia and the Baltic countries; however, the possible effects of plantations on the native European aspen (P.
Koivuranta, Leena   +2 more
doaj   +1 more source

Effects of Epistasis and Pleiotropy on Fitness Landscapes [PDF]

open access: yesarXiv, 2013
The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic architecture -- affect the structure of the fitness landscape, and how they affect the ability of ...
arxiv  

Fine-Structure Map of the Histidine Transport Genes in \u3cem\u3eSalmonella typhimurium\u3c/em\u3e [PDF]

open access: yes, 1977
Afine-structure genetic map of the histidine transport region of the Salmonella typhimurium chromosome was constructed. Twenty-five deletion mutants were isolated and used for dividing the hisJ and hisP genes into 8 and 13 regions respectively.
Afong, J.   +6 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Variable selection with genetic algorithms using repeated cross-validation of PLS regression models as fitness measure [PDF]

open access: yesarXiv, 2017
Genetic algorithms are a widely used method in chemometrics for extracting variable subsets with high prediction power. Most fitness measures used by these genetic algorithms are based on the ordinary least-squares fit of the resulting model to the entire data or a subset thereof. Due to multicollinearity, partial least squares regression is often more
arxiv  

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