Results 81 to 90 of about 372,355 (336)

On genetic correlation estimation with summary statistics from genome-wide association studies [PDF]

arXiv, 2019
Genome-wide association studies (GWAS) have been widely used to examine the association between single nucleotide polymorphisms (SNPs) and complex traits, where both the sample size n and the number of SNPs p can be very large. Recently, cross-trait polygenic risk score (PRS) method has gained extremely popular for assessing genetic correlation of ...
arxiv  

Genetic Dissection of Cytonuclear Epistasis in Line Crosses [PDF]

Genetics, 2007
Abstract Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL × cytoplasm interactions to the phenotypic ...
Zefeng Yang, Xuefeng Wang, Chenwu Xu, Zhiqiu Hu, Zaixiang Tang   +4 more
openaire   +3 more sources

Circular 82 [PDF]

, 1991
The development of improved plant cultivars is accomplished through comprehensive plant breeding programs. Such programs: 1) evaluate genetically-diverse germplasm in order to identify superior-performing genotypes; 2) create new genetic ...
Blake, Steve A., Dofing, Stephen M., Knight, Charles W.   +2 more
core  

Reproductive success through high pollinator visitation rates despite self incompatibility in an endangered wallflower [PDF]

, 2016
PREMISE OF THE STUDY: Self incompatibility (SI) in rare plants presents a unique challenge—SI protects plants from inbreeding depression, but requires a sufficient number of mates and xenogamous pollination. Does SI persist in an endangered polyploid? Is
Herman, Julie A., Lucas, Jessica, Melen, Miranda K., O’Malley, Rachel E., Parker, Ingrid M., Thom, Aaron M., Whittall, Justen B.   +6 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Demonstration of a genetic-algorithm-optimized cavity-based waveguide crossing [PDF]

arXiv, 2017
A compact, single-etch silicon photonics waveguide crossing based on low quality factor cavity and optimized by a genetic algorithm is demonstrated. The device has 0.1~0.3 dB insertion loss and < -35 dB crosstalk per crossing for fundamental TE mode in the 1550-1600 nm wavelength band, with a footprint of 5 x 5 {\mu}m$^2$.
arxiv  

Genetic analysis in the Collaborative Cross breeding population [PDF]

Genome Research, 2011
Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history of these inbred panels may influence detectable allelic and phenotypic diversity. The existing panel of common inbred strains reflects historical selection biases, and existing recombinant inbred ...
Philip, Vivek M, Sokoloff, Greta, Ackert-Bicknell, Cheryl L, Striz, Martin, Branstetter, Lisa, Beckmann, Melissa A, Spence, Jason S, Jackson, Barbara L, Galloway, Leslie D, Barker, Paul, Wymore, Ann M, Hunsicker, Patricia R, Durtschi, David C, Shaw, Ginger S, Shinpock, Sarah, Manly, Kenneth F, Miller, Darla R, Donohue, Kevin D, Culiat, Cymbeline T, Churchill, Gary A, Lariviere, William R, Palmer, Abraham A, O'Hara, Bruce F, Voy, Brynn H, Chesler, Elissa J   +24 more
openaire   +3 more sources

Circular 79 [PDF]

, 1990
The development of improved cultivars of barley is accomplished through comprehensive plant breeding programs. Such programs: 1). evaluate genetically-diverse germplasm in order to identify superiorperforming genotypes; 2).
Blake, S.A., Dofing, S.M.
core  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Optimized breeding strategies to harness genetic resources with different performance levels

BMC Genomics, 2020
Background The narrow genetic base of elite germplasm compromises long-term genetic gain and increases the vulnerability to biotic and abiotic stresses in unpredictable environmental conditions. Therefore, an efficient strategy is required to broaden the
Antoine Allier, Simon Teyssèdre, Christina Lehermeier, Laurence Moreau, Alain Charcosset   +4 more
doaj   +1 more source