Results 31 to 40 of about 136,313 (321)
Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis
CellsThe extracellular matrix (ECM) provides structural support for tissues and regulatory signals for resident cells. ECM requires a careful balance between protein accumulation and degradation for homeostasis.
Sarah M. Lloyd, Yupeng He
doaj +1 more source
Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks [PDF]
, 2011 The actin cytoskeleton in living cells has many types of crosslinkers. The mechanical interplay between these different crosslinker types is an open issue in cytoskeletal mechanics. We develop a framework to study the cooperativity and redundancy in the mechanics of filamentous networks with two types of crosslinkers: crosslinkers that allow free ...
arxiv +1 more source
In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability [PDF]
, 2021 The design of antibacterial-releasing coatings or wrapping materials with controlled drug release capability is a promising strategy to minimise risks of infection and medical device failure in vivo. Collagen fibres have been employed as medical device building block, although they still fail to display controlled release capability, competitive wet ...
arxiv +1 more source
MicromachinesCollagen-based scaffolds have been widely used in tissue engineering. The alignment of collagen fibers and the degree of crosslinking in engineering tissue scaffolds significantly affect cell activity and scaffold stability.
Shengmao Lin +5 more
doaj +1 more source
Suitability of EGCG as a Means of Stabilizing a Porcine Osteochondral Xenograft
Journal of Functional Biomaterials, 2017 As a non-crosslinked osteochondral xenograft would be mechanically inferior to native cartilage and vulnerable to premature degradation, we seek a safe and effective method of xenograft stabilization.
Steven Elder +3 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Development of in situ bioprinting: A mini review
Frontiers in Bioengineering and Biotechnology, 2022 Bioprinting has rapidly progressed over the past decade. One branch of bioprinting known as in situ bioprinting has benefitted considerably from innovations in biofabrication.
Aidan MacAdam +7 more
doaj +1 more source
Crosslinker energy landscape effects on dynamic mechanical properties of ideal polymer hydrogels [PDF]
arXiv, 2023 Reversible crosslinkers can enable several desirable mechanical properties, such as improved toughness and self-healing, when incorporated in polymer networks for bioengineering and structural applications. In this work, we performed coarse-grained molecular dynamics to investigate the effect of the energy landscape of reversible crosslinkers on the ...
arxiv
A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini +11 more
wiley +1 more source
Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations
Beilstein Journal of Organic Chemistry, 2014 Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features.
Sebastian Reinelt +5 more
doaj +1 more source