Results 51 to 60 of about 197,806 (310)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Modification of Silk Fibers via β-cyclodextrin – Empirical Modeling and Process Optimization Using Response Surface Methodology

Journal of Natural Fibers, 2020
Modification of silk fabric via grafting with β-cyclodextrin (β-CD) using citric acid (CA) as a cross-linking agent was studied and optimized. A four-factor central composite design combined with response surface methodology (RSM) was employed to ...
Leila Mehraz, Mahdi Nouri
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The effects of crosslinking byproducts on the electrical properties of low density polyethylene

, 2011
Crosslinked polyethylene (XLPE) is widely used for high voltage insulation in power transmission systems. However, it has been found that, after crosslinking with Dicumyl Peroxide (DCP), the crosslinking byproducts such as acetophenone, ?-methylstyrene ...
Hussin, Nuriziani
core   +1 more source

A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking

Frontiers in Bioengineering and Biotechnology, 2019
The study of corneal biomechanics is motivated by the tight relationship between biomechanical properties and visual function within the ocular system.
Brecken J. Blackburn, Brecken J. Blackburn, Brecken J. Blackburn, Brecken J. Blackburn, Michael W. Jenkins, Michael W. Jenkins, Andrew M. Rollins, William J. Dupps, William J. Dupps   +8 more
doaj   +1 more source

Exogenous Crosslinking of Tendons as a Strategy for Mechanical Augmentation and Repair: A Narrative Review

, 2023
Alexandru Fofiu,1,2 Robert G Tripon,3 Tiberiu Băţagă,4 Traian V Chirilă2,5– 8 1Department of Orthopedics-Traumatology, Emergency County Hospital Bistriţa, Bistriţa Năsăud, Romania; 2School of ...
Băţagă T, Fofiu A, Tripon RG, Chirilă TV   +3 more
core  

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Management of pediatric keratoconus - Evolving role of corneal collagen cross-linking: An update

Indian Journal of Ophthalmology, 2013
Pediatric keratoconus demonstrates several distinctive management issues in comparison with adult keratoconus with respect to under-diagnosis, poor compliance and modifications in treatment patterns.
Vardhaman P Kankariya, George D Kymionis, Vasilios F Diakonis, Sonia H Yoo   +3 more
doaj   +1 more source

Photo-enzymatic dityrosine crosslinking for bioprinting [PDF]

, 2022
In this research work, we demonstrate photo-triggering of the horseradish peroxidase (HRP) dityrosine crosslinking. The photo-enzymatic crosslinking of tyramine modified alginate was obtained by introducing riboflavin as a photosensitizer, and by ...
Perin, F., Mota, C., Maniglio, D., Mota, C.; id_orcid, Motta, A., Mancini, I.   +5 more
core   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source