Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis
CellsThe extracellular matrix (ECM) provides structural support for tissues and regulatory signals for resident cells. ECM requires a careful balance between protein accumulation and degradation for homeostasis.
Sarah M. Lloyd, Yupeng He
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Antioxidants, 2023 Nanofibers, produced through the novel method of electrospinning, have a high ratio of surface area to volume, which allows them to have different optical, electrical, thermal, and mechanical properties than macroscale materials.
Reem Hasan +4 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Effects of Crosslinking Methods on Network Structure and Enzymatic Degradation of Methacrylate-Functionalized Chitosan Hydrogel [PDF]
, 2018 Polysaccharides, such as hyaluronic acid, alginate, or chitosan, can be modified by addition of reactive functional groups to enable chemical crosslinking.
Juhong Ahn (6067943) +7 more
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Optical Correction of Keratoconus with a Scleral Gas-Permeable Lenses
Oftalʹmologiâ, 2019 The optical properties of the cornea are determined by its ability to refract and transmit light. Keratoconus changes cornea’s shape, the surface of the cornea becomes irregular, which leads to a violation of light refraction and the occurrence of ...
A. V. Myagkov +4 more
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The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks inmammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 [PDF]
, 2005 SJG-136, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine bases in a 5'-GATC-3' sequence in the DNA minor groove.
Hartley, J.A. +13 more
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Insights on Chemical Crosslinking Strategies for Proteins
, 2022 Crosslinking of proteins has gained immense significance in the fabrication of biomaterials for various health care applications. Various novel chemical-based strategies are being continuously developed for intra-/inter-molecular crosslinking of proteins
Chanda, Kaushik +9 more
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Ophthalmology and TherapyKeratoconus is the most common corneal ectatic disorder worldwide. Typically manifesting in adolescence, it imposes a substantial burden on quality of life and, if untreated, may progress to advanced stages requiring corneal transplantation.
Cosimo Mazzotta +5 more
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Tough Materials Through Ionic Interactions
Frontiers in Chemistry, 2021 This article introduces butyl acrylate-based materials that are toughened with dynamic crosslinkers. These dynamic crosslinkers are salts where both the anion and cation polymerize.
Linda Salminen +3 more
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