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Some Effects of Heat-Labile Venom Components on Indirect Hemolysis by Crotalid Venoms

The American Journal of Tropical Medicine and Hygiene, 1970
Abstract The hemolytic activities of the venom of Agkistrodon contortrix mokeson, Agkistrodon piscivorus leucostoma, Crotalus atrox, and Crotalus scutulatus were studied by using hypotonic solutions. The effects with whole venoms plus lecithin were compared with effects caused by boiled venom supernatant fluids containing phospholipase A and lecithin ...
F E, Byrd, B D, Johnson
openaire   +4 more sources

Crotalid Snake Venom Subproteomes Unraveled by the Antiophidic Protein DM43

Journal of Proteome Research, 2009
Snake venoms are mixtures of proteins and peptides with different biological activities, many of which are very toxic. Several animals, including the opossum Didelphis aurita, are resistant to snake venoms due to the presence of neutralizing factors in their blood. An antihemorrhagic protein named DM43 was isolated from opossum serum. It inhibits snake
Surza L G, Rocha   +7 more
openaire   +4 more sources

Affinity-Purified, Mixed Monospecific Crotalid Antivenom Ovine Fab for the Treatment of Crotalid Venom Poisoning

Annals of Emergency Medicine, 1997
To test the efficacy and safety of a new antivenom, affinity-purified, mixed monospecific crotalid antivenom ovine Fab, in human subjects with minimal or moderate crotalid envenomation.We conducted a prospective multicenter clinical trial of 11 patients 10 years or older with progressive manifestations after mild to moderate crotalid snakebite.
R C, Dart   +8 more
openaire   +4 more sources

Effects of Crotalid Venom on North American Snakes

Copeia, 1942
A LTHOUGH the question of the susceptibility of snakes to their own venom, or to venom of other species, has been of interest for some time, relatively little experimental work has been undertaken in this field. Most reports in the literature cite examples in which one snake was seen to bite another.
Hugh L. Keegan, Ted F. Andrews
openaire   +3 more sources

Neutralization of kinin-releasing enzymes of crotalid venoms by monospecific and polyspecific antivenoms

Toxicon, 1991
The amounts of kinin-releasing enzymes in the venoms of Crotalus atrox, Crotalus adamanteus, Crotalus scutulatus scutulatus and Agkistrodon piscivorus piscivorus were measured by determining the amounts of kinin released from a sheep kininogen substrate by means of a specific radioimmunoassay. Four monospecific and two commercial polyspecific antivenom
G S, Bailey   +3 more
openaire   +4 more sources

Antigenic relationships between Mojave toxin subunits, Mojave toxin and some crotalid venoms

Toxicon, 1986
Immunochemical responses of a number of pit viper venoms to antibodies derived separately from the acidic and basic subunits were investigated by enzyme linked immunosorbent assay (ELISA) and Ouchterlony immunodiffusion. The polyclonal antisera to the basic subunit were generated in rabbits, whereas mouse hybridoma cell cultures were used to produce ...
J T, Henderson, A L, Bieber
openaire   +4 more sources

Isolation and characterization of myotoxic phospholipases A2 from crotalid venoms

Toxicon, 1986
Phospholipases A2 producing myonecrosis when injected i.m. into mice were isolated from venoms of Trimeresurus flavoviridis, Agkistrodon bilineatus, A. c. contortrix, A. c. mokeson, A. p. piscivorus and Bothrops asper by gels filtration on Sephadex G-75 followed by ion-exchange chromatography on CM-cellulose.
D, Mebs, Y, Samejima
openaire   +2 more sources

Surgical technique for isolation of the main venom gland of viperid, crotalid and elapid snakes

Toxicon, 1973
Abstract The main venom glands of venomous snakes were isolated in situ by a harmless surgical technique. The surgery had no apparent effect on the snakes' appearance, disposition or feeding habits more than 2 years after surgery. The snake, after surgery, could serve as an excellent preparation for studying the venom secretory process in the main ...
J L, Glenn, R, Straight, C C, Snyder
openaire   +3 more sources

A rapid method for the purification of monomeric and/or dimeric phospholipases A2 in crotalid snake venoms

Toxicon, 1985
We have developed a simple two-step procedure for the separation of monomeric (14,000 mol. wt) and dimeric (28,000 mol. wt) phospholipases A2 from the venoms of Crotalidae family snakes. All venom phospholipases A2 studied thus far exist as monomers under acidic conditions and are chromatographed as such on a column of G-50 Sephadex (superfine ...
W, Welches   +3 more
openaire   +2 more sources

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