Results 31 to 40 of about 3,099 (216)

Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus. [PDF]

Acta Crystallogr D Biol Crystallogr, 2013
The crystal structure of the myotoxic, cell-penetrating, basic polypeptide crotamine isolated from the venom ofCrotalus durissus terrificushas been determined by single-wavelength anomalous dispersion techniques and refined at 1.7 Å resolution. The structure reveals distinct cationic and hydrophobic surface regions that are located on opposite sides of
Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C.   +6 more
europepmc   +6 more sources

Avaliação em camundongo da eficácia do antiveneno administrado no local da inoculação intramuscular do veneno de Crotalus durissus terrificus Evaluation in mice, of the antivenom efficacy injected at the same place of the intramuscular inoculation of the Crotalus durissus terrificus venom [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1993
A eficácia do antiveneno crotálico por via intramuscular (im) no local da inoculação, também im, do veneno de Crotalus durissus terrificus foi avaliada em camundongos.
Lindioneza Adriano Ribeiro, Carla Lilian Agostini Utescher, Silvia Lucia Paro Vieira, Sara Fensterseifer, Helena Mukuno, Miguel Tanús Jorge   +5 more
doaj   +2 more sources

Crotalus durissus terrificus venom as a source of antitumoral agents [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase ...
MA Soares, PB Pujatti, CL Fortes-Dias, L Antonelli, RG Santos   +4 more
doaj   +4 more sources

American rattlesnake (Crotalus durissus terrificus) bite accidents in dogs in Argentina

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2000
The symptomatology and treatment of two dogs bitten by Crotalus durissus terrificus are described. Neurological signs were present few minutes after the accident with local anesthesia and ataxia of the affected limb and neurotoxic fascia.
P. Koscinczuk, O. Acosta de Pérez, P. Teibler, S. Maruñak, A.S. Rosciani   +4 more
doaj   +2 more sources

An evaluation of 3-rhamnosylquercetin, a glycosylated form of quercetin, against the myotoxic and edematogenic effects of sPLA 2 from Crotalus durissus terrificus. [PDF]

Biomed Res Int, 2014
Toyama Dde O, Gaeta HH, de Pinho MV, Ferreira MJ, Romoff P, Matioli FF, Magro AJ, Fontes MR, Toyama MH.   +8 more
europepmc   +3 more sources

In vivo and in vitro prospection of the anti-ophidic properties exercised by the extracts of Jacaranda decurrens L.

Acta Scientiarum: Biological Sciences, 2021
The research and development of alternative treatments for snakebites (e.g., medicinal plants) is necessary due to the high costs of the existing ones.
Marcus Vinícius Cardoso Trento, Mateus Santos Carapiá, Pedro Henrique Souza César, Mariana Aparecida Braga, Andreimar Martins Soares, Silvana Marcussi   +5 more
doaj   +1 more source

Afibrinogenemia Following Snake Bite (Crotalus Durissus Terrificus) [PDF]

The American Journal of Tropical Medicine and Hygiene, 1980
Following the bite of Crotalus durissus terrificus, an 11-year-old boy developed afibrinogenemia and high output acute renal failure. His platelet count remained within normal limits. He was treated with epsilon aminocaproic acid and whole fresh blood transfusion, with full recovery from afibrinogenemia 40 hours after the beginning of these measures ...
C F, Amaral, O A, da Silva, M, López, E R, Pedroso   +3 more
openaire   +2 more sources

Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023
Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori, Giulia Lodigiani, Stella G. Colombarolli, Greta Bergamaschi, Alberto Vitali   +4 more
wiley   +1 more source

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

New generation of cell‐penetrating peptides: Functionality and potential clinical application

Journal of Peptide Science, Volume 27, Issue 5, May 2021., 2021
New generation of CPPs achieves high uptake efficiency, cell‐ and tissue‐selective internalization, escape from endosomes, stability against proteases, and low toxicity against healthy cells. Certain members are derived from natural sources, and some of them exhibit innate tumor selectivity.
Siegmund Reissmann, Margarita P. Filatova   +1 more
wiley   +1 more source