Results 21 to 30 of about 1,015 (165)

Purification, crystallization and preliminary X-ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snakeCrotalus durissus terrificus [PDF]

Acta Crystallographica Section F: Structural Biology Communications, 2012
Patrick Spencer, Christian Betzel, Monika A Coronado   +2 more
exaly   +2 more sources

Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023
Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori, Giulia Lodigiani, Stella G. Colombarolli, Greta Bergamaschi, Alberto Vitali   +4 more
wiley   +1 more source

Geographic variation of individual venom profile of Crotalus durissus snakes [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution.
Leandro Norberto da Silva-Júnior, Lara de Souza Abreu, Caroline Fabri Bittencourt Rodrigues, Nathália da Costa Galizio, Weslei da Silva Aguiar, Caroline Serino-Silva, Valdomiro Souza dos Santos, Isabella Alves Costa, Luis Vicente Franco Oliveira, Sávio Stefanini Sant’Anna, Kathleen Fernandes Grego, Anita Mitico Tanaka-Azevedo, Leandro Nascimento da Silva Rodrigues, Karen de Morais-Zani   +13 more
doaj   +1 more source

Crotalus durissus terrificus venom as a source of antitumoral agents [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase patients' survival. Snake venoms are natural sources of bioactive substances with therapeutic potential.
Soares, MA, Pujatti, PB, Fortes-Dias, CL, Antonelli, L, Santos, RG   +4 more
openaire   +4 more sources

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

New generation of cell‐penetrating peptides: Functionality and potential clinical application

Journal of Peptide Science, Volume 27, Issue 5, May 2021., 2021
New generation of CPPs achieves high uptake efficiency, cell‐ and tissue‐selective internalization, escape from endosomes, stability against proteases, and low toxicity against healthy cells. Certain members are derived from natural sources, and some of them exhibit innate tumor selectivity.
Siegmund Reissmann, Margarita P. Filatova   +1 more
wiley   +1 more source

Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature‐Based Undivided Perspective

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Dengue remains one of the most serious and widespread mosquito‐borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths.
Muhammad Torequl Islam, Cristina Quispe, Jesús Herrera-Bravo, Chandan Sarkar, Rohit Sharma, Neha Garg, Larry Ibarra Fredes, Miquel Martorell, Mohammed M. Alshehri, Javad Sharifi-Rad, Sevgi Durna Daştan, Daniela Calina, Radi Alsafi, Saad Alghamdi, Gaber El-Saber Batiha, Natália Cruz-Martins, Cassiano Felippe Gonçalves-de-Albuquerque   +16 more
wiley   +1 more source

Quadros clínico-patológicos do envenenamento ofídico por Crotalus durissus terrificus e Bothrops spp. em animais de produção [PDF]

Pesquisa Veterinária Brasileira, 2014
Foi realizada uma revisão dos quadros clínico-patológicos causados pelos venenos de Crotalus durissus terrificus e Bothrops spp. em bovinos, búfalos, ovinos equinos e suínos.
Carlos Hubinger Tokarnia, Marilene Farias Brito, José Diomedes Barbosa, Jürgen Döbereiner   +3 more
doaj   +3 more sources

Liver dysfunction in patients bitten by Crotalus durissus terrificus (Laurenti, 1768) snakes in Botucatu (State of São Paulo, Brazil) Alterações hepáticas em doentes picados por serpentes Crotalus durissus terrificus (Laurenti, 1768) na região de Botucatu, Estado de São Paulo, Brasil

Revista do Instituto de Medicina Tropical de São Paulo, 1995
Thirty-two patients bitten by venomous snakes sixteen by Bothrops spp. and sixteen by Crotalus durissus terrificus were studied. The group comprised thirty males and two females, aged eight to sixty-three years (mean 33±15).
Benedito Barra Viera, Kunie Yabuki Rabello Coelho, Paulo Roberto Curi, Domingos Alves Meira   +3 more
doaj   +1 more source

Spatial Structure Explains Morphological Variation Better Than Climatic Gradients in the South American Rattlesnake (Crotalus durissus) [PDF]

Ecol Evol
We evaluated whether climatic gradients or spatial structure better explain body size variation in the South American rattlesnake (Crotalus durissus) across its wide geographic range. After explicitly accounting for spatial autocorrelation, climatic variables were not significant predictors of body size in either sex, whereas sex‐specific spatial ...
Otani M, Costa H, Zawadzki C, Santana D.
europepmc   +2 more sources