Results 21 to 30 of about 5,223 (185)

Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira, Rui Seabra Ferreira, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos, Daniel Carvalho Pimenta   +6 more
doaj   +2 more sources

Crotalus durissus terrificus venom as a source of antitumoral agents [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase ...
MA Soares, PB Pujatti, CL Fortes-Dias, L Antonelli, RG Santos   +4 more
doaj   +4 more sources

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions [PDF]

Mediators of Inflammation, 2001
Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2.
Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky   +4 more
doaj   +2 more sources

Techniques of artificial insemination in Crotalus durissus terrificus (Viperidae-Crotalinae)

, 1994
Machos e fêmeas (n= 12) de Crotalus durissus terrificus, nascidos em cativeiro foram usados para testar a técnica de Inseminação Artificial. O esperma diluído foi introduzido na vagina e após 120 dias, 3 fêmeas foram dissecadas para exame. Outras 3 tiverarn a gestação levada a termo e produziram filhotes normais. Não foram observados ovos atrésicos.
Langlada, Francisco Garcia de, Santos, Selma, Ferreira, Iara Lucia Laporta   +2 more
openaire   +3 more sources

In vivo and in vitro prospection of the anti-ophidic properties exercised by the extracts of Jacaranda decurrens L.

Acta Scientiarum: Biological Sciences, 2021
The research and development of alternative treatments for snakebites (e.g., medicinal plants) is necessary due to the high costs of the existing ones.
Marcus Vinícius Cardoso Trento, Mateus Santos Carapiá, Pedro Henrique Souza César, Mariana Aparecida Braga, Andreimar Martins Soares, Silvana Marcussi   +5 more
doaj   +1 more source

Peptidase activities in Crotalus durissus terrificus semen [PDF]

Reproduction, 2008
Abstract To understand the role of peptidases in seminal physiology of Crotalus durissus terrificus, activity levels of representative enzymes in semen and their sensitivities to inhibitors, cofactors, and peptide hormones were evaluated.
Camila Eduardo, Marinho, Selma Maria, Almeida-Santos, Sylvia Mendes, Carneiro, Simone Cristina, Yamasaki, Paulo Flavio, Silveira   +4 more
openaire   +2 more sources

The origin of the diversity of crotoxin isoforms in the venom of Crotalus durissus terrificus [PDF]

European Journal of Biochemistry, 1994
Crotoxin, the main toxin from the venom of the South American rattlesnake Crotalus durissus terrificus, is a β‐neurotoxin which consists of the non‐covalent association of two subunits: a phospholipase A2 subunit B (CB), and a non‐enzymic subunit A (CA).
G, Faure, V, Choumet, C, Bouchier, L, Camoin, J L, Guillaume, B, Monegier, M, Vuilhorgne, C, Bon   +7 more
openaire   +2 more sources

Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023
Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori, Giulia Lodigiani, Stella G. Colombarolli, Greta Bergamaschi, Alberto Vitali   +4 more
wiley   +1 more source

Geographic variation of individual venom profile of Crotalus durissus snakes [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution.
Leandro Norberto da Silva-Júnior, Lara de Souza Abreu, Caroline Fabri Bittencourt Rodrigues, Nathália da Costa Galizio, Weslei da Silva Aguiar, Caroline Serino-Silva, Valdomiro Souza dos Santos, Isabella Alves Costa, Luis Vicente Franco Oliveira, Sávio Stefanini Sant’Anna, Kathleen Fernandes Grego, Anita Mitico Tanaka-Azevedo, Leandro Nascimento da Silva Rodrigues, Karen de Morais-Zani   +13 more
doaj   +1 more source

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source