Results 51 to 60 of about 22,516 (228)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Localized Prostate Cancer Therapy: Tumor Microenvironment‐Activated Spermine Hydrogel With Real‐Time Autonomous Fluorescence Sensing

Chemistry – A European Journal, EarlyView.
First tumor microenvironment (TME)‐responsive spermine‐loaded hydrogel with autonomous sensing for advanced local therapy of prostate cancer (PCa) is developed. Spermine can be released from the hydrogel to kill the prostate cancer cells specifically under acidic TME.
Ho‐Fai Chau, Wing‐Sze Tam, Gengguo Deng, Yik Hoi Yeung, Christine Yim Ping Wong, Ka Lo Cheng, Zhengxiao Liu, Lijia Yao, Yi Wang, Angelo H. All, Chi‐Fai Ng, Jinming Di, Ka‐Leung Wong   +12 more
wiley   +1 more source

Novel and bone-targeted agents for CRPC

Annals of Oncology, 2012
Clearly, no neoplasm other than prostate cancer has benefited from so many breakthroughs since the beginning of this decade: the past two years can be considered exceptional due to the number of emerging agents against castration-resistant prostate cancer (CRPC), which have demonstrated positive outcomes in phase III trials.
K, Fizazi, L, Albiges, C, Massard, B, Escudier, Y, Loriot   +4 more
openaire   +2 more sources

Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators

, 2021
Androgen deprivation therapy (ADT) is the mainstay regimen in patients with androgen-dependent prostate cancer (PCa). However, the selection of androgen-independent cancer cells leads to castrate resistant prostate cancer (CRPC). The aggressive phenotype
Mardhekar, Nikhil, Narwani, Devin, Notta, Shahnawaz, Mondal, Debasis, Quadri, Syed S. A., Ghaffar, Dawood   +5 more
core  

Development of Neuroendocrine Prostate Cancers by the Ser/Arg Repetitive Matrix 4-Mediated RNA Splicing Network

Frontiers in Oncology, 2018
While the use of next-generation androgen receptor pathway inhibition (ARPI) therapy has significantly increased the survival of patients with metastatic prostate adenocarcinoma (AdPC), several groups have reported a treatment-resistant mechanism ...
Ahn R. Lee, Nicole Che, Jessica M. Lovnicki, Xuesen Dong   +3 more
doaj   +1 more source

Fluorescent Colored Passive Radiative Cooling Based on Carbon Dots for Cooling Power Recovery

EcoEnergy, EarlyView.
We demonstrate colored passive radiative coolers consisting of a highly reflective porous ceramic base covered by an eco‐friendly luminescent carbon dot‐polymer composite, with two types of carbon dots enabling conversion of either ultraviolet or visible light, respectively.
Lin Liang, Chui Ting Kwok, Maksim Miropoltsev, Kaixin Lin, Elena V. Ushakova, Yang Fu, Wenqi Wang, Hao Li, Dong Lv, Yihao Zhu, Wenjie Liu, Andrey L. Rogach, Chi Yan Tso   +12 more
wiley   +1 more source

Peran PDCD4 Serum dan Jaringan Prostat pada Perkembangan Pasien Castrate Resistant Prostate Cancer (CRPC)

, 2023
Kanker prostat berasal dari kelenjar prostat dan dapat terjadi karena proliferasi sel atau kegagalan apoptosis. Secara global, kanker prostat adalah kanker keempat yang paling umum ditemukan setelah kanker payudara, paru-paru, dan kolorektal.
Dr. dr. Hani Susianti, Sp. PK(K), Dr. dr. Kurnia Penta Seputra, Sp.U(K), Dr. dr. Besut Daryanto, Sp.B, Sp.U(K), Purnomo, dr. Athaya Febriantyo   +3 more
core  

Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage

BMC Complementary Medicine and Therapies, 2021
Background Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrated to exhibit anticancer efficacy ...
Ding-fang Zhang, Zhi-chun Yang, Jian-qiang Chen, Xiang-xiang Jin, Yin-da Qiu, Xiao-jing Chen, Hong-yi Shi, Zhi-guo Liu, Min-shan Wang, Guang Liang, Xiao-hui Zheng   +10 more
doaj   +1 more source

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

International Journal of Cancer, EarlyView.
ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia, Daniele Santini, Marc R. Matrana, Marco Maruzzo, Ray Manneh Kopp, Lorenzo Antonuzzo, Sergio Bracarda, Deniz Tural, Giuseppe Procopio, Maria T. Bourlon, Orazio Caffo, Martin Ignacio Zapata Laguado, Massimo Di Maio, Brigida Anna Maiorano, Vincenza Conteduca, Sabrina Rossetti, Helga Lipari, Thomas Büttner, Mimma Rizzo, Yüksel Ürün, Carlo Messina, Fernando Sabino Marques Monteiro, Andrey Soares, Mattia Puglisi, Alice Principi, Eleonora Lai, Giulia Mammone, Marco Stellato, Ilaria Depetris, Tancredi Didier Bazan Russo, Isadora Yasbick Spricido, Camila Bobato Lara Gismondi, Francesco Massari, Nicola Pavan, Matteo Santoni, Tarek Taha   +35 more
wiley   +1 more source

Forest plot with hazard ratio (HR) of OS in subgroup of HSPC and CRPC.

, 2022
Forest plot with hazard ratio (HR) of OS in subgroup of HSPC and CRPC.
Mandi Lin (13844322), Xinxiang Fan (467985), Songtao Xiang (5949191), Weiting Qin (467615), Chiwei Chen (13844319), Renlun Huang (7871009), Daocheng Yu (13844325), Jianfu Zhou (13844328), Lang Guo (9276449)   +8 more
core   +1 more source