Results 121 to 130 of about 1,018 (177)

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities. [PDF]

Front Pharmacol, 2023
Porta EOJ, Kalesh K, Steel PG.
europepmc   +1 more source

Protozoan Neglected Tropical Diseases (NTDs) Target Inhibition of Alkaloids from <i>Croton linearis</i> Jacq Leaves: A Molecular Docking and ADMET Approach. [PDF]

Pharmaceuticals (Basel)
Rojas-Vargas JA, García-Díaz J, Escalona-Arranz JC, Chlebek J, Monzote L, Setzer WN, Castillo-Garit JA.   +6 more
europepmc   +1 more source

Inhibitors of Proteases: A Well-Grounded Strategy in Drug Development. [PDF]

Molecules
Previti S, Ettari R.
europepmc   +1 more source

The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors. [PDF]

Mini Rev Med Chem
Dos Santos Nascimento IJ, Gomes JNS, de Oliveira Viana J, de Medeiros E Silva YMS, Barbosa EG, de Moura RO.   +5 more
europepmc   +1 more source

Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (<i>Trypanosoma cruzi</i> and <i>Leishmania mexicana</i>) and Anti-<i>Mycobacterium tuberculosis</i> Agents. [PDF]

Pharmaceutics
Delgado-Maldonado T, Navarrete-Carriola DV, Vázquez-Jiménez LK, Paz-González AD, Wan B, Franzblau S, Mohammed OM, Rodríguez-Páez L, Aguirre-Alvarado C, Alcántara-Farfán V, Cordero-Martínez J, Bandyopadhyay D, Moreno-Rodríguez A, Rivera G.   +13 more
europepmc   +1 more source

Anti-<i>Trypanosoma cruzi</i> Potential of New Pyrazole-Imidazoline Derivatives. [PDF]

Molecules
de Oliveira EC, Lara LDS, Orlando LMR, Lanera SDC, de Souza TP, Figueiredo NDS, Paes VB, Mazzochi AC, Fernandes PHM, Dos Santos MS, Pereira MCS.   +10 more
europepmc   +1 more source

Thiosulfonate-Based Targeted Covalent Cruzipain Inhibitors with Enhanced Bioactivity Translation for Antichagasic Therapy. [PDF]

ACS Med Chem Lett
Cerutti JP, Diniz LA, Corrêa Santos V, Vilchez Larrea SC, Alonso GD, Ferreira RS, Dehaen W, Quevedo MA.   +7 more
europepmc   +1 more source

Combining Charge Density Analysis with Machine Learning Tools To Investigate the Cruzain Inhibition Mechanism

ACS Omega, 2019
Adriano M. Luchi, Roxana N. Villafañe, J. Leonardo Gómez Chávez, M. Lucrecia Bogado, Emilio L. Angelina, Nelida M. Peruchena   +5 more
doaj   +1 more source

Computational Study of the Michaelis Complex Formation and the Effect on the Reaction Mechanism of Cruzain Cysteine Protease

ACS Omega, 2018
Kemel Arafet, Katarzyna Świderek, Vicent Moliner   +2 more
doaj   +1 more source

Pyrazole-Imidazoline Derivative Prevents Cardiac Damage and Mortality in Acute <i>Trypanosoma cruzi</i> Infection. [PDF]

Pharmaceuticals (Basel)
Orlando LMR, Lara LDS, de Souza TP, Paes VB, Calvet CM, de Mesquita LB, Lechuga GC, Pereira CN, Dos Santos MS, Pereira MCS.   +9 more
europepmc   +1 more source