Results 101 to 110 of about 133,701 (285)

Common lines modeling for reference free ab-initio reconstruction in cryo-EM

, 2017
We consider the problem of estimating an unbiased and reference-free ab-inito model for non-symmetric molecules from images generated by single-particle cryo-electron microscopy.
Greenberg, Ido, Shkolnisky, Yoel
core   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum

Nature Communications
Bacteriophages offer a promising alternative to drug-based treatments due to their effectiveness and host specificity. This is particularly important in agriculture as a biocontrol agent of plant diseases.
James Hodgkinson-Bean, Rafael Ayala, Nadishka Jayawardena, Georgia L. Rutter, Bridget N. J. Watson, David Mayo-Muñoz, James Keal, Peter C. Fineran, Matthias Wolf, Mihnea Bostina   +9 more
doaj   +1 more source

Energy-filtered transmission electron microscopy of biological samples on highly transparent carbon nanomembranes

, 2011
Ultrathin carbon nanomembranes (CNM) comprising crosslinked biphenyl precursors have been tested as support films for energy-filtered transmission electron microscopy (EFTEM) of biological specimens.
Beyer, André, Büenfeld, Matthias, Gölzhäuser, Armin, Hampp, Norbert, Kühlbrandt, Werner, Rhinow, Daniel, Turchanin, Andrey, Weber, Nils-Eike   +7 more
core   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Electromagnetic lensing using the Aharonov–Bohm effect

New Journal of Physics
We demonstrate theoretically and experimentally an electromagnetic lensing concept using the magnetic vector potential—in a region free of classical electromagnetic fields—via the Aharonov–Bohm (AB) effect.
Makoto Tokoro Schreiber, Cathal Cassidy, Menour Saidani, Matthias Wolf   +3 more
doaj   +1 more source

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source

Structural insights into the human P2X1 receptor and ligand interactions

Nature Communications
The P2X1 receptor is a trimeric ligand-gated ion channel that plays an important role in urogenital and immune functions, offering the potential for new drug treatments.
Felix M. Bennetts, Hariprasad Venugopal, Alisa Glukhova, Jesse I. Mobbs, Sabatino Ventura, David M. Thal   +5 more
doaj   +1 more source

Recent advances in retroviruses via cryo-electron microscopy

Retrovirology, 2018
Cryo-electron microscopy has undergone a revolution in recent years and it has contributed significantly to a number of different areas in biological research.
Johnson Mak, Alex de Marco
doaj   +1 more source

Native cellular architecture of Treponema denticola revealed by cryo-electron tomography [PDF]

, 2009
Using cryo-electron tomography, we are developing a refined description of native cellular structures in the pathogenic spirochete Treponema denticola. Tightly organized bundles of periplasmic flagella were readily observed in intact plunge-frozen cells.
Hsieh, Chyong-Ere, Izard, Jacques, Limberger, Ronald J., Mannella, Carmen A., Marko, Michael   +4 more
core   +1 more source