Results 91 to 100 of about 2,310,044 (293)

CryoEM screening with a blotting instrument: quantifying parameters affecting ice thickness using semi-automated image analysis

Methods in Microscopy
Cryo-electron microscopy (cryoEM) grid preparation is one of the bottlenecks in using cryoEM for macromolecular structure determination. Despite significant advancements in the development of blot-free instruments, their high cost limits their widespread
Valimehr Sepideh, Cho Ellie, Brown Hamish G., McMillan Paul J., Hanssen Eric   +4 more
doaj   +1 more source

Resolving Nanoscale Heterogeneities in Lead Halide Perovskites Through Low‐Dose Concurrent 4D‐STEM‐EDX Mapping

Advanced Materials, EarlyView.
Mixed‐cation lead mixed‐halide perovskites suffer from structural instabilities linked to nanoscale heterogeneity. To probe this non‐destructively, a low‐dose, concurrent 4D‐STEM and EDX methodology has been developed. Examining a (FA0.83Cs0.17)Pb(I0.8Br0.2)3 film revealed a complex mosaic of coexisting crystal structures. Crucially, local deficiencies
Jinseok Ryu, Alexandra A. Sheader, Mohsen Danaie, David G. Hopkinson, Katherine E. MacArthur, Nakita K. Noel, Christopher S. Allen   +6 more
wiley   +1 more source

Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum

Nature Communications
Bacteriophages offer a promising alternative to drug-based treatments due to their effectiveness and host specificity. This is particularly important in agriculture as a biocontrol agent of plant diseases.
James Hodgkinson-Bean, Rafael Ayala, Nadishka Jayawardena, Georgia L. Rutter, Bridget N. J. Watson, David Mayo-Muñoz, James Keal, Peter C. Fineran, Matthias Wolf, Mihnea Bostina   +9 more
doaj   +1 more source

Flagellar Motility and Structure in the Hyperthermoacidophilic Archaeon Sulfolobus solfataricus [PDF]

, 2007
Flagellation in archaea is widespread and is involved in swimming motility. Here, we demonstrate that the structural flagellin gene from the crenarchaeaon Sulfolobus solfataricus is highly expressed in stationary-phase-grown cells and under unfavorable ...
Szabó, Zalán,, Blum, Paul, Groeneveld, Maarten,, Sani, Musa,, Driessen, Arnold J. M., Albers, Sonja-Verena,, Zolghadr, Behnam, Zolghadr, Benham,, Albers, Sonja-Verena, Boekema, Egbert J.,, Albers, Sonja Verena, Groeneveld, Maarten, Blum, Paul,, Schelert, James, Sani, Musa, Szabo, Zalan, Zolghadr, Benham, Schelert, James,, Boekema, Egbert J., Driessen, Arnold J.M.,   +19 more
core   +2 more sources

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy [PDF]

, 2017
Bacteria downregulate their ribosomal activity through dimerization of 70S ribosomes, yielding inactive 100S complexes. In Escherichia coli, dimerization is mediated by the hibernation promotion factor (HPF) and ribosome modulation factor. Here we report
Guskov, Albert, Gert T. Oostergetel, Pranav Puri, Poolman, Berend, Linda E. Franken, Valentina Arkhipova, Albert Guskov, Franken, Linda, Oostergetel, Gerrit, Guskov, Albert; id_orcid, Bert Poolman, Boekema, Egbert, Tjaard Pijning, Pijning, Tjaard; id_orcid, Puri, Pranav, Pijning, Tjaard, Egbert J. Boekema, Arkhipova, Valentina Ivanovna   +17 more
core   +2 more sources

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

Structural insights into the human P2X1 receptor and ligand interactions

Nature Communications
The P2X1 receptor is a trimeric ligand-gated ion channel that plays an important role in urogenital and immune functions, offering the potential for new drug treatments.
Felix M. Bennetts, Hariprasad Venugopal, Alisa Glukhova, Jesse I. Mobbs, Sabatino Ventura, David M. Thal   +5 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Electromagnetic lensing using the Aharonov–Bohm effect

New Journal of Physics
We demonstrate theoretically and experimentally an electromagnetic lensing concept using the magnetic vector potential—in a region free of classical electromagnetic fields—via the Aharonov–Bohm (AB) effect.
Makoto Tokoro Schreiber, Cathal Cassidy, Menour Saidani, Matthias Wolf   +3 more
doaj   +1 more source