Results 71 to 80 of about 68,000 (256)

Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum

Nature Communications
Bacteriophages offer a promising alternative to drug-based treatments due to their effectiveness and host specificity. This is particularly important in agriculture as a biocontrol agent of plant diseases.
James Hodgkinson-Bean, Rafael Ayala, Nadishka Jayawardena, Georgia L. Rutter, Bridget N. J. Watson, David Mayo-Muñoz, James Keal, Peter C. Fineran, Matthias Wolf, Mihnea Bostina   +9 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

CryoEM screening with a blotting instrument: quantifying parameters affecting ice thickness using semi-automated image analysis

Methods in Microscopy
Cryo-electron microscopy (cryoEM) grid preparation is one of the bottlenecks in using cryoEM for macromolecular structure determination. Despite significant advancements in the development of blot-free instruments, their high cost limits their widespread
Valimehr Sepideh, Cho Ellie, Brown Hamish G., McMillan Paul J., Hanssen Eric   +4 more
doaj   +1 more source

Progress on the Failure Mechanisms and Optimization Strategies on Lithium Iron Phosphate

Advanced Materials Interfaces, EarlyView.
This review centers on LiFeO4 cathodes, outlining their core advantages and performance limitations, then systematically elucidating failure mechanisms, proposing key optimization strategies, and summarizing future research directions that integrate advanced characterization with intelligent design.
Zheng‐Xin Qian, Tianxiang Li, Zhijiang Liu, Mingzhe Yuan, Xiaoyu Gu, Banglong Wan, Qian Zhao, Zuotong Zha, Hang Ma   +8 more
wiley   +1 more source

Structural insights into the human P2X1 receptor and ligand interactions

Nature Communications
The P2X1 receptor is a trimeric ligand-gated ion channel that plays an important role in urogenital and immune functions, offering the potential for new drug treatments.
Felix M. Bennetts, Hariprasad Venugopal, Alisa Glukhova, Jesse I. Mobbs, Sabatino Ventura, David M. Thal   +5 more
doaj   +1 more source

Solid Particle‐Liquid Metal Mixtures for Robust High‐Current Interconnects in Stretchable Electronics and Soft Robotics

Advanced Materials Technologies, EarlyView.
Metallic microparticles dispersed in liquid metal interconnects mitigate electromigration‐induced failure by reconfiguring internal current density distributions. These fillers facilitate the growth of a robust, protective gallium oxide shell at elevated temperatures, shifting the failure threshold toward a thermal limit.
Ethan J. Krings, Calan Brant, Carson Emeigh, Donovan Vincent Jr., Ravi Tutika, Sangjin Ryu, Eric J. Markvicka   +6 more
wiley   +1 more source

Electromagnetic lensing using the Aharonov–Bohm effect

New Journal of Physics
We demonstrate theoretically and experimentally an electromagnetic lensing concept using the magnetic vector potential—in a region free of classical electromagnetic fields—via the Aharonov–Bohm (AB) effect.
Makoto Tokoro Schreiber, Cathal Cassidy, Menour Saidani, Matthias Wolf   +3 more
doaj   +1 more source

Coaxial Melt Electrowriting

Advanced Materials Technologies, EarlyView.
Coaxial melt electrowriting is established to produce dual‐property microfibers with diameters spanning 1.6–29.2 µm. Stable coaxial laminar flow is preserved under electrohydrodynamic thinning, enabling controlled binary and gradient material switching within individual continuous fibers.
Patrick C. Hall, D. Iman von Briesen, Maya Kasteleiner, Gabriela M. Bailey, Diana Ostojich, Harrison W. Reid, Andre Olarra, Benjamín J. Alemán, Simon Luposchainsky, Biranche Tandon, Ramesh Jasti, Paul D. Dalton   +11 more
wiley   +1 more source

Recent advances in retroviruses via cryo-electron microscopy

Retrovirology, 2018
Cryo-electron microscopy has undergone a revolution in recent years and it has contributed significantly to a number of different areas in biological research.
Johnson Mak, Alex de Marco
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source