Results 51 to 60 of about 133,701 (285)

Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography [PDF]

, 2013
Focused-ion beam lift-out and annular milling is the most common method used for obtaining site specific specimens for atom probe tomography (APT) experiments and transmission electron microscopy.
І.Г. Леонов, А.Є. Присяжний, В.А. Присяжний, Д.С. Сидоренко, И.Г. Леонов, А.Е. Присяжный, В.А. Присяжный, Д.С. Сидоренко, I.G. Leonov, A.Y. Prisyazhniy, V.A. Prisyazhniy, D.S. Sidorenko   +11 more
core   +2 more sources

CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS

Annual Review of Biophysics and Biomolecular Structure, 2006
Splicing is an essential step of gene expression in which introns are removed from pre-mRNA to generate mature mRNA that can be translated by the ribosome. This reaction is catalyzed by a large and dynamic macromolecular RNP complex called the spliceosome. The spliceosome is formed by the stepwise integration of five snRNPs composed of U1, U2, U4, U5,
Stark, H., Luehrmann, R.
openaire   +4 more sources

A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization

Biomolecules, 2023
Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi, Trevor T. Dean, Karine Minari, Luis G. M. Basso, Tyler D. R. Vance, Vitor Hugo B. Serrão   +5 more
doaj   +1 more source

Alternative mechanism for bacteriophage adsorption to the motile bacterium Caulobacter crescentus [PDF]

, 2011
2D and 3D cryo-electron microscopy, together with adsorption kinetics assays of ϕCb13 and ϕCbK phage-infected Caulobacter crescentus, provides insight into the mechanisms of infection.
Ackermann, Adrian, Agabian-Keshishian, B. Ely, Bender, Bendis, Berg, Bradley, Briegel, Brinton, Chibeu, E. R. Wright, Edgar, Evinger, Fukuda, Fukuda, Fukuda, G. J. Jensen, Hinz, Huitema, J. S. Poindexter, Jollick, Kremer, Lagenaur, Lake, Leonard, Leonard, M. Georgieva, P. H. Viollier, Papadopoulos, Poindexter, Poindexter, Pope, Pruggnaller, R. C. Guerrero-Ferreira, Radhakrishnan, Raimondo, Samuel, Schade, SCHMIDT, SCHMIDT, Scholl, Skerker, Sommer, Zheng, Zhilenkov   +45 more
core   +4 more sources

BioEM: GPU-accelerated computing of Bayesian inference of electron microscopy images

, 2016
In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM (BioEM) formalism ...
Baruffa, Fabio, Cossio, Pilar, Hummer, Gerhard, Lindenstruth, Volker, Rampp, Markus, Rohr, David   +5 more
core   +1 more source

Purification and electron cryomicroscopy of coronavirus particles. [PDF]

, 2008
Intact, enveloped coronavirus particles vary widely in size and contour, and are thus refractory to study by traditional structural means such as X-ray crystallography. Electron microscopy (EM) overcomes some problems associated with particle variability
Adair, Brian D, Buchmeier, Michael J, Neuman, Benjamin W, Yeager, Mark   +3 more
core   +1 more source

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

eLife, 2023
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal   +23 more
doaj   +1 more source

Structural basis of complement membrane attack complex formation [PDF]

, 2015
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit’ mechanism; however, sublytic MAC pores on host cells activate ...
Bubeck, D, Giles, JL, Morgan, BP, Serna Gil, M   +3 more
core   +1 more source

Thermoresponsive Hydrogels with Improved Actuation Function by Interconnected Microchannels

Advanced Intelligent Systems, 2022
Stimuli−responsive hydrogels are important in soft actuators research, as they change volume in response to environmental factors. Thermoresponsive hydrogels, such as poly(N‐isopropylacrylamide) (pNIPAM), typically have slow response rates and exert ...
Tobias Spratte, Christine Arndt, Irene Wacker, Margarethe Hauck, Rainer Adelung, Rasmus R. Schröder, Fabian Schütt, Christine Selhuber-Unkel   +7 more
doaj   +1 more source

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. [PDF]

, 2019
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Afonine, Afonine, Allen, Angus-Hill, Ashkenazy, Ashkenazy, Asturias, Badis, Buchan, Buchan, Cairns, Cairns, Campsteijn, Chaban, Chambers, Chatterjee, Clapier, Clapier, Côté, Da, Dechassa, Duan, Dutta, Dürr, El-Gebali, Emsley, Erkina, Filippakopoulos, Goddard, Han, Jones, Jones, Kadoch, Kasten, Klein-Brill, Krietenstein, Kuryan, Leschziner, Leschziner, Li, Liu, Lopéz-Blanco, Mashtalir, Morin, Nagai, Nakane, Ng, Patel, Pettersen, Puig, Saha, Sammak, Schorb, Schubert, Sen, Shim, Sievers, Skiniotis, Smith, Suloway, Söding, Tan, Tsunaka, Ungar, Valencia, Wagner, Wang, Wilson, Xia, Yan, Yang, Ye, Yen, Zhang, Zhang, Zhang, Zheng, Zivanov, Zivanov, Zukin   +79 more
core   +3 more sources