Results 31 to 40 of about 2,310,044 (293)
Strain engineering in alloy nanoparticles
Advances in Physics: X, 2023 The deformation of interatomic distances with respect to those of the perfect crystal generates atomic-level strain. In nanoalloys, strain can arise because of finite size, morphology, domain structure and lattice mismatch between their atomic compounds.
Diana Nelli +2 more
doaj +1 more source
Optimized cryo-EM data-acquisition workflow by sample-thickness determination [PDF]
, 2021 Sample thickness is a known key parameter in cryo-electron microscopy (cryo-EM) and can affect the amount of high-resolution information retained in the image. Yet, common data-acquisition approaches in single-particle cryo-EM do not take it into account.
Resch, Guenter P +3 more
core +2 more sources
Cryo-electron microscopy of membrane proteins [PDF]
Methods, 2018 Membrane proteins represent a large proportion of the proteome, but have characteristics that are problematic for many methods in modern molecular biology (that have often been developed with soluble proteins in mind). For structural studies, low levels of expression and the presence of detergent have been thorns in the flesh of the membrane protein ...
Nopnithi, Thonghin +3 more
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Cryo-electron microscopy of the chromatin fiber
Current Opinion in Structural Biology, 2020 The three-dimensional (3D) organization of chromatin plays a crucial role in the regulation of gene expression. Chromatin conformation is strongly affected by the composition, structural features and dynamic properties of the nucleosome, which in turn determine the nature and geometry of interactions that can occur between neighboring nucleosomes ...
Boopathi, Ramachandran +4 more
openaire +6 more sources
Cryo-electron microscopy of the giant viruses
Microscopy, 2021 Abstract High-resolution study of the giant viruses presents one of the latest challenges in cryo-electron microscopy (EM) of viruses. Too small for light microscopy but too large for easy study at high resolution by EM, they range in size from ∼0.2 to 2 μm from high-symmetry icosahedral viruses, such as Paramecium burseria Chlorella ...
Raymond N, Burton-Smith +1 more
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Cryo-electron microscopy of chromatin biology [PDF]
Acta Crystallographica Section D Structural Biology, 2017 The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in eukaryotic cells is compacted, replicated and read. Since its discovery, biochemists have sought to understand how this protein–DNA complex can help to control so many diverse tasks.
Marcus D. Wilson, Alessandro Costa
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Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy
Acta Neuropathologica Communications, 2018 Nemaline myopathies are heterogeneous congenital muscle disorders causing skeletal muscle weakness and, in some cases, death soon after birth. Mutations in nebulin, encoding a large sarcomeric protein required for thin filament function, are responsible ...
Tamar E. Sztal +5 more
doaj +1 more source
Transfer of tilted sample information in transmission electron microscopy [PDF]
, 2010 When a transmission electron microscope is used in imaging mode, information carried by the sample function is transformed by the optics of the instrument during the imaging process.
Mariani, Valerio
core +1 more source
A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization
Biomolecules, 2023 Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi +5 more
doaj +1 more source
Cryo-electron microscopy of vitrified specimens [PDF]
Quarterly Reviews of Biophysics, 1988 Cryo-electron microscopy of vitrified specimens was just emerging as a practical method when Richard Henderson proposed that we should teach an EMBO course on the new technique. The request seemed to come too early because at that moment the method looked more like a laboratory game than a useful tool.
Dubochet, Jacques +6 more
openaire +3 more sources