Results 11 to 20 of about 2,310,044 (293)
Artificial Intelligence in Cryo-Electron Microscopy
Life, 2022 Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the structure of macromolecular complexes. The biological function of macromolecular complexes is inextricably tied to the flexibility of these complexes.
Jeong Min Chung +2 more
doaj +5 more sources
Recent Advances in Cryo Electron Microscopy and Tomography [PDF]
Structural DynamicsIn the recent years, cryo-electron microscopy (cryo-EM) single-particle analysis (SPA) has greatly benefited from a multitude of technological advances cumulating in breaking the atomic-resolution barrier for biological macromolecules.
Eliza Nieweglowska +2 more
doaj +5 more sources
Cryo‐electron microscopy of cholinesterases, present and future [PDF]
Journal of Neurochemistry, 2020 AbstractAcetylcholinesterase (AChE) and butyrylcholinesterase (BChE) exist in a variety of oligomeric forms, each with defined cellular and subcellular distributions. Although crystal structures of AChE and BChE have been available for many years, structures of the physiologically relevant ChE tetramer were only recently solved by cryo‐electron ...
Miguel Ricardo Leung +1 more
core +7 more sources
3D solutions in transmission electron (Cryo) -microscopy in biology [PDF]
, 2012 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166One of the main problems in transmission electron microscopy in the biological field is the tri-dimensionality.
Muela, Yolanda +4 more
core +6 more sources
Transmission electron microscopy in cell biology: sample preparation techniques and image information [PDF]
, 2012 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166Transmission electron microscopy is a proven technique in the field of cell biology and a very useful tool in biomedical research. Innovation and improvements in equipment together with
Cortadellas i Raméntol, Núria +2 more
core +7 more sources
Cryo-electron microscopy-based drug design [PDF]
Frontiers in Molecular BiosciencesStructure-based drug design (SBDD) has gained popularity owing to its ability to develop more potent drugs compared to conventional drug-discovery methods.
Ecenur Cebi +5 more
doaj +2 more sources
Assembly mechanism of the pleomorphic immature poxvirus scaffold
Nature Communications, 2022 Immature poxviruses are characterized by nonicosahedral semiordered protein scaffolds critical for morphogenesis. Here, the authors use cryo-EM structures of Vaccinia virus D13 scaffold intermediates to explain their assembly mechanism.
Jaekyung Hyun +3 more
doaj +1 more source
Nature Communications, 2023 The portal-scaffold complex is believed to nucleate the assembly of herpesvirus procapsids. During capsid maturation, two events occur: scaffold expulsion and DNA incorporation. The portal-scaffold interaction and the conformational changes that occur to
Zhihai Li +5 more
doaj +1 more source
Cohomology of Cryo-Electron Microscopy [PDF]
SIAM Journal on Applied Algebra and Geometry, 2017 The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimensional structure of a molecule from a collection of its 2-dimensional projected images. In this article, we show that the basic premise of cryo-EM --- patching together 2-dimensional projections to reconstruct a 3-dimensional object --- is naturally one of Cech cohomology with SO(2)-
Ke Ye, Lek-Heng Lim
openaire +2 more sources
Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
Nature Communications, 2023 Great effort has been devoted to discovering the basis of A3G-Vif interaction, the key event of HIV’s counteraction mechanism to evade antiviral innate immune response.
Takahide Kouno +6 more
doaj +1 more source