Results 21 to 30 of about 6,053 (258)
Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes
Cell Reports, 2021 Summary: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity. Multiple GLP-1R agonists have entered into clinical trials,
Xin Zhang +5 more
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CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS
Annual Review of Biophysics and Biomolecular Structure, 2006 Splicing is an essential step of gene expression in which introns are removed from pre-mRNA to generate mature mRNA that can be translated by the ribosome. This reaction is catalyzed by a large and dynamic macromolecular RNP complex called the spliceosome. The spliceosome is formed by the stepwise integration of five snRNPs composed of U1, U2, U4, U5,
Stark, H., Luehrmann, R.
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Cryo-electron microscopy of vitrified specimens [PDF]
Quarterly Reviews of Biophysics, 1988 Cryo-electron microscopy of vitrified specimens was just emerging as a practical method when Richard Henderson proposed that we should teach an EMBO course on the new technique. The request seemed to come too early because at that moment the method looked more like a laboratory game than a useful tool.
Dubochet, Jacques +6 more
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Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nature Communications, 2022 The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the ...
Purushotham Selvakumar +10 more
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Strain engineering in alloy nanoparticles
Advances in Physics: X, 2023 The deformation of interatomic distances with respect to those of the perfect crystal generates atomic-level strain. In nanoalloys, strain can arise because of finite size, morphology, domain structure and lattice mismatch between their atomic compounds.
Diana Nelli +2 more
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The cryo-electron microscopy structure of huntingtin [PDF]
Nature, 2018 Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and the regulation of transcription. Although an integrative understanding of the biological functions of HTT is lacking, the large number of identified HTT ...
Guo, Q. +13 more
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Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy
Acta Neuropathologica Communications, 2018 Nemaline myopathies are heterogeneous congenital muscle disorders causing skeletal muscle weakness and, in some cases, death soon after birth. Mutations in nebulin, encoding a large sarcomeric protein required for thin filament function, are responsible ...
Tamar E. Sztal +5 more
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Cryo-electron microscopy of chromatin biology [PDF]
Acta Crystallographica Section D Structural Biology, 2017 The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in eukaryotic cells is compacted, replicated and read. Since its discovery, biochemists have sought to understand how this protein–DNA complex can help to control so many diverse tasks.
Marcus D. Wilson, Alessandro Costa
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Cryo-electron microscopy of the giant viruses
Microscopy, 2021 Abstract High-resolution study of the giant viruses presents one of the latest challenges in cryo-electron microscopy (EM) of viruses. Too small for light microscopy but too large for easy study at high resolution by EM, they range in size from ∼0.2 to 2 μm from high-symmetry icosahedral viruses, such as Paramecium burseria Chlorella ...
Raymond N, Burton-Smith +1 more
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Cryo‐electron microscopy of cholinesterases, present and future [PDF]
Journal of Neurochemistry, 2020 AbstractAcetylcholinesterase (AChE) and butyrylcholinesterase (BChE) exist in a variety of oligomeric forms, each with defined cellular and subcellular distributions. Although crystal structures of AChE and BChE have been available for many years, structures of the physiologically relevant ChE tetramer were only recently solved by cryo‐electron ...
Miguel Ricardo Leung +1 more
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