Results 111 to 120 of about 2,439,094 (286)

Structural insights into the human P2X1 receptor and ligand interactions

Nature Communications
The P2X1 receptor is a trimeric ligand-gated ion channel that plays an important role in urogenital and immune functions, offering the potential for new drug treatments.
Felix M. Bennetts, Hariprasad Venugopal, Alisa Glukhova, Jesse I. Mobbs, Sabatino Ventura, David M. Thal   +5 more
doaj   +1 more source

Image Restoration in Cryo-Electron Microscopy [PDF]

, 2010
Image restoration techniques are used to obtain, given experimental measurements, the best possible approximation of the original object within the limits imposed by instrumental conditions and noise level in the data. In molecular electron microscopy (EM), we are mainly interested in linear methods that preserve the respective relationships between ...
openaire   +2 more sources

Cryo-electron microscopy structure of full-length PCV2 VLPs.

, 2019
(A) Typical raw cryo EM image of PCV2 VLPs imaged at the magnification of 67,000× under Titan Krios electron microscopy. (B) 2D classification of PCV2 VLP particles from the EM images collected under 300 kV.
Bo Yin (681235), Kegong Tian (30834), Xiaobing Mo (6416606), Xiangdong Li (343463), Adam Yuan (6416609), Junhua Deng (4708246)   +5 more
core   +1 more source

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

, 2023
Cryo-focused ion beam (cryo-FIB) milling technology has been developed for the fabrication of cryo-lamella of frozen native specimens for study by in situ cryo-electron tomography (cryo-ET).
Chen Qi, Gang Ji, Fei Sun, Wei Xu, Xing Jia, Xiaoyun Zhang, Hongyu Deng, Tongxin Niu, Shuoguo Li   +8 more
core   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Electromagnetic lensing using the Aharonov–Bohm effect

New Journal of Physics
We demonstrate theoretically and experimentally an electromagnetic lensing concept using the magnetic vector potential—in a region free of classical electromagnetic fields—via the Aharonov–Bohm (AB) effect.
Makoto Tokoro Schreiber, Cathal Cassidy, Menour Saidani, Matthias Wolf   +3 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Towards correlative super‐resolution fluorescence and electron cryo‐microscopy [PDF]

, 2016
Correlative light and electron microscopy (CLEM) has become a powerful tool in life sciences. Particularly cryo-CLEM, the combination of fluorescence cryo-microscopy (cryo-FM) permitting for non-invasive specific multi-colour labelling, with electron ...
Kay Grünewald, Christoph Hagen, Rainer Kaufmann, Georg Wolff   +3 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

4D Cryo-Electron Microscopy of Proteins

, 2016
Cryo-electron microscopy is a form of transmission electron microscopy that has been used to determine the 3D structure of biological specimens in the hydrated state and with high resolution.
Ulrich J. Lorenz (1865794), Giovanni M. Vanacore (1561033), Anthony W. P. Fitzpatrick (450396), Ahmed H. Zewail (1561030)   +3 more
core   +1 more source