Results 111 to 120 of about 2,310,044 (293)

Introduction to high-resolution cryo-electron microscopy

Postępy Biochemii, 2016
For many years two techniques have dominated structural biology – X-ray crystallography and NMR spectroscopy. Traditional cryo-electron microscopy of biological macromolecules produced macromolecular reconstructions at resolution limited to 6–10 Å.
Mariusz, Czarnocki-Cieciura, Marcin, Nowotny   +1 more
openaire   +3 more sources

Coaxial Melt Electrowriting

Advanced Materials Technologies, EarlyView.
Coaxial melt electrowriting is established to produce dual‐property microfibers with diameters spanning 1.6–29.2 µm. Stable coaxial laminar flow is preserved under electrohydrodynamic thinning, enabling controlled binary and gradient material switching within individual continuous fibers.
Patrick C. Hall, D. Iman von Briesen, Maya Kasteleiner, Gabriela M. Bailey, Diana Ostojich, Harrison W. Reid, Andre Olarra, Benjamín J. Alemán, Simon Luposchainsky, Biranche Tandon, Ramesh Jasti, Paul D. Dalton   +11 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Comparative analysis of extracellular vesicles released from resting neutrophils under distinct pharmacological inhibition

Scientific Reports
Cells in resting conditions spontaneously release extracellular vesicles (EVs). Comparative studies for pharmacological EV inhibition, targeting multiple biogenesis elements within the same cell type, remain scarce.
Viktória Szeifert, Alexa Szeifert, William Randall Arnold, Azusa Terasaki, Keshav Bhatnagar, Derick Okwan-Duodu   +5 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Biomedical and biological applications of scanning electron microscopy [PDF]

, 2012
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166This article summarizes the basic principles of scanning electron microscopy and the capabilities of the technique with different examples of applications in biomedical and biological ...
Cortadellas i Raméntol, Núria, García, Almudena, Fernández, Eva   +2 more
core   +2 more sources

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

CEMOVIS; cryo-electron microscopy of vitreous sections

, 2008
Institut für AnatomieNotes: 2008016244 GBA7A2002 edited by Annie Cavalier, Danièle Spehner, Bruno M. Humbel. ill. ; 26 cm. Includes bibliographical references and index. Slam-freezing, metal-mirror freezing / Danièle Spehner and Ludwig Edelmann -- Plunge-
Al-Amoudi, A., Dubochet, J., Bouchet-Marquis, C., Zuber, Benoît, Eltsov, M.   +4 more
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Interlayer‐Sliding‐Enabled Multiferroicity and Giant Switchable Anomalous Hall Conductivity in RuO2Zn2F2 Bilayer

Advanced Science, EarlyView.
Interlayer sliding in the RuO2Zn2F2 bilayer induces ferroelectricity and enables reversible valley polarization switching. The electric dipole and valley‐resolved band edges are intimately coupled, revealing sliding ferroelectricity as a powerful mechanism for electrical control of valley degrees of freedom in 2D materials.
Djamel Bezzerga, Imran Khan, Ganie Suhail Ahmad, Jisang Hong   +3 more
wiley   +1 more source