Results 151 to 160 of about 132,225 (219)

Cryo-Electron Microscopy Reaches Resolution Milestone

ACS Central Science, 2020
Mark Peplow
doaj   +1 more source

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets. [PDF]

Nat Commun
Molinarolo S, Valdivia CR, Valdivia HH, Van Petegem F.   +3 more
europepmc   +1 more source

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Nanoscopic Imaging the Lithiation of Sulfur Nanoparticles under Electron Beam Irradiation

Advanced Science, EarlyView.
ABSTRACT In situ Transmission Electron Microscopy (TEM) provides powerful insights into the reaction mechanisms of Lithium‐Sulfur (Li‐S) batteries. However, distinguishing intrinsic electrochemical behaviors from artifacts induced by high‐energy electron beam irradiation remains a critical challenge.
Rui Huang, Xingyu Zhang, Xingqi Liao, Ruilin Bai, Xianqi Wu, Junlei Xiang, Sheng Cheng, Yifan Zhang, Jing Wang, Hongfa Xiang, Juyeong Kim, Qiaobao Zhang, Yu Yao, Xiaohui Song   +13 more
wiley   +1 more source

Hepatitis B Virus Assembly: Cryo-Electron Microscopy Reveals Structure of the Surface Antigen. [PDF]

MedComm (2020)
Li G, Cui J, Nie J.
europepmc   +1 more source

A Shear Thickening Colloidal Suspension Functioning via Progressive Impact Jamming with Persistent Lubrication Layer

Advanced Science, EarlyView.
An ionic liquid‐based shear‐thickening fluid (ILSTF) exhibits lubricated dynamics from strong shear thickening to impact‐triggered jamming. A persistent nanometric solvation layer around silica governs both the shear thickening saturation in rheology and jamming front propagation under dynamic impact compression.
Yiran Wu, Yifeng Yu, Yiqiu Zhao, Qin Xu, T. X. Yu, Xin Zhang, Jinglei Yang   +6 more
wiley   +1 more source

Structural basis for T-cell intracellular antigen-1 amyloid fibril formation revealed by cryo-electron microscopy. [PDF]

PNAS Nexus
Inaoka D, Miyata T, Makino F, Ohtani Y, Ekari M, Kobayashi R, Imamura K, Sakamoto E, Kodama TS, Yoshida N, Kato T, Namba K, Tochio H, Sekiyama N.   +13 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

In situ cryo-electron microscopy and tomography of cellular and organismal samples. [PDF]

Curr Opin Struct Biol
Majumder P, Zhang P.
europepmc   +1 more source

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source