Results 11 to 20 of about 99,841 (293)
IUCrJ, 2022 The 2022 meeting of the American Crystallographic Association in Portland was an inspiring event, addressing a range of both conventional and emerging themes in structural biology. The increasing emphasis at the conference on methods outside the conventional envelope of crystallography, especially cryo-electron microscopy, is discussed.
Sriram Subramaniam +2 more
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Proteins: Structure, Function, and Bioinformatics, 2021 Abstract Structures of seven CASP14 targets were determined using cryo‐electron microscopy (cryo‐EM) technique with resolution between 2.1 and 3.8 Å. We provide an evaluation of the submitted models versus the experimental data (cryo‐EM density maps) and experimental reference structures built into the maps.
Tristan Cragnolini +2 more
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Applications and prospects of cryo-EM in drug discovery
Military Medical Research, 2023 Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming.
Kong-Fu Zhu +10 more
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Current Biology, 2018 Eva Nogales introduces cryo-electron microscopy used to visualize macromolecular structures.
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Cryo-EM map interpretation and protein model-building using iterative map segmentation. [PDF]
, 2020 A procedure for building protein chains into maps produced by single-particle electron cryo-microscopy (cryo-EM) is described. The procedure is similar to the way an experienced structural biologist might analyze a map, focusing first on secondary ...
Afonine PV +9 more
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CLIC: a pogram on cultivating true leadership [PDF]
, 2012 12 May 2012. A Program on cultivating true leadership skills helped participants became more effective team members. Solving jigsaw puzzles using leaders’ portraits, putting leader related situations into drawings, stepping oneself into a leader’s shoe ...
Chung, Pui Khi +5 more
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Frontiers in Molecular Biosciences, 2022 An increasing number of protein complex structures are determined by cryo-electron microscopy (cryo-EM). When individual protein structures have been determined and are available, an important task in structure modeling is to fit the individual ...
Eman Alnabati +4 more
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Nature Methods, 2015 Gold supports nearly eliminate unwanted specimen motion in cryo-electron microscopy, enabling high-resolution structure determination of challenging proteins.
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IUCrJ, 2020 The application of cryo-EM methods to study SARS-CoV-2 proteins provides a convincing demonstration of the power of cryo-EM in the arsenal of structural biology.
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Purification and electron cryomicroscopy of coronavirus particles. [PDF]
, 2008 Intact, enveloped coronavirus particles vary widely in size and contour, and are thus refractory to study by traditional structural means such as X-ray crystallography. Electron microscopy (EM) overcomes some problems associated with particle variability
Adair, Brian D +3 more
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