Results 41 to 50 of about 6,328,527 (298)
Accelerating discovery and rational engineering of antibody modalities using Cryo- EM [PDF]
Structural DynamicsAs the need for novel therapeutic modalities is growing, researchers require innovative strategies and transformative technologies to overcome the limitations of traditional antibody discovery methodologies.
Tilak Gupta, Surajit Banerjee
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Cryo-EM: beyond the microscope [PDF]
Current Opinion in Structural Biology, 2017 The pace at which cryo-EM is being adopted as a mainstream tool in structural biology has continued unabated over the past year. Initial successes in obtaining near-atomic resolution structures with cryo-EM were enabled to a large extent by advances in microscope and detector technology.
Lesley A, Earl +3 more
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A Bayesian approach to extracting free-energy profiles from cryo-electron microscopy experiments
Scientific Reports, 2021 Cryo-electron microscopy (cryo-EM) extracts single-particle density projections of individual biomolecules. Although cryo-EM is widely used for 3D reconstruction, due to its single-particle nature it has the potential to provide information about a ...
Julian Giraldo-Barreto +6 more
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Cryo-EM data collection, processing, and validation.
, 2023 Cryo-EM data collection, processing, and validation.
Anila Yasmeen (460713) +13 more
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, 2015 These video lectures by Professor Grant Jensen cover the fundamental principles underlying cryo-electron microscopy (cryo-EM) starting with the basic anatomy of electron microscopes, an introduction to Fourier transforms, and the principles of image ...
Jensen, Grant J.
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iScience, 2021 Summary: Cellular factories engage numerous highly complex “molecular machines” to perform pivotal biological functions. 3D structural visualization is an effective way to understand the functional mechanisms of these biomacromolecules.
Aneek Banerjee +2 more
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Cryo-EM data collection and refinement parameters.
, 2022 Cryo-EM data collection and refinement parameters.
Jarrod B. French (1328283) +3 more
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Medicines, 2019 Background: Cryo-electron microscopy (cryo-EM) has become a major technique for protein structure determination. However, due to the low quality of cryo-EM density maps, many protein structures derived from cryo-EM contain outliers introduced during the ...
Lin Chen +4 more
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MembranesThe application of cryo-electron microscopy (cryo-EM) in membrane protein structural biology has catalyzed unprecedented advances in our understanding of fundamental biological processes and transformed drug discovery paradigms.
Vitor Hugo Balasco Serrão
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Routine sub-2.5 Å cryo-EM structure determination of GPCRs
Nature Communications, 2021 There is a need to optimise cryo-EM data acquisition approaches to improve the resolution of GPCR cryo-EM structures to better than 2.5 Å, in order to use them for structure-based drug design purposes.
Radostin Danev +6 more
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