Results 21 to 30 of about 99,841 (293)
Protein Science, 2016 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/135551/1/pro3088 ...
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Cryo-EM in drug discovery [PDF]
Biochemical Society Transactions, 2019 Abstract The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including direct electron detectors, automation, better microscope vacuums and lenses, phase plates and ...
Tom Ceska +4 more
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Cryo‐EM structures of coagulation factors
Research and Practice in Thrombosis and Haemostasis, 2022 A State of the Art lecture titled “Cryo‐EM structures of coagulation factors” was presented at the ISTH Congress in 2022. Cryogenic electron microscopy (cryo‐EM) is a revolutionary technique capable of solving the structure of high molecular weight ...
Enrico Di Cera +3 more
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A Bayesian approach to extracting free-energy profiles from cryo-electron microscopy experiments
Scientific Reports, 2021 Cryo-electron microscopy (cryo-EM) extracts single-particle density projections of individual biomolecules. Although cryo-EM is widely used for 3D reconstruction, due to its single-particle nature it has the potential to provide information about a ...
Julian Giraldo-Barreto +6 more
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iScience, 2021 Summary: Cellular factories engage numerous highly complex “molecular machines” to perform pivotal biological functions. 3D structural visualization is an effective way to understand the functional mechanisms of these biomacromolecules.
Aneek Banerjee +2 more
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Scientific Video Protocols, 2020 Richard Henderson discusses Jacques Dubochet's, Joachim Frank's and his contributions to the development of electron cryo-microscopy.
Richard Henderson, Mejd Alsari
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Accelerating discovery and rational engineering of antibody modalities using Cryo- EM [PDF]
Structural DynamicsAs the need for novel therapeutic modalities is growing, researchers require innovative strategies and transformative technologies to overcome the limitations of traditional antibody discovery methodologies.
Tilak Gupta, Surajit Banerjee
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Cryo-EM: beyond the microscope [PDF]
Current Opinion in Structural Biology, 2017 The pace at which cryo-EM is being adopted as a mainstream tool in structural biology has continued unabated over the past year. Initial successes in obtaining near-atomic resolution structures with cryo-EM were enabled to a large extent by advances in microscope and detector technology.
Lesley A, Earl +3 more
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Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]
, 2013 In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa +68 more
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Data-Driven Tight Frame for Cryo-EM Image Denoising and Conformational Classification
, 2018 The cryo-electron microscope (cryo-EM) is increasingly popular these years. It helps to uncover the biological structures and functions of macromolecules. In this paper, we address image denoising problem in cryo-EM. Denoising the cryo-EM images can help
Cai, Jian-Feng +6 more
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