Results 21 to 30 of about 6,313,615 (343)
Current Biology, 2018 Eva Nogales introduces cryo-electron microscopy used to visualize macromolecular structures.
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Cryo-EM data collection and refinement statistics of PfFNT.
, 2021 cryo-EM, cryo-electron microscopy; PfFNT, P. falciparum formate–nitrite transporter. (DOCX)
Yanxia Zhou (1447465) +17 more
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Applications and prospects of cryo-EM in drug discovery
Military Medical Research, 2023 Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming.
Kong-Fu Zhu +10 more
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Protein Science, 2016 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/135551/1/pro3088 ...
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Cryo-EM data, refinement, and validations.
, 2022 Cryo-EM data, refinement, and validations.
Gerald S. Baron (300505) +10 more
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Cryo-EM in drug discovery [PDF]
Biochemical Society Transactions, 2019 Abstract The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including direct electron detectors, automation, better microscope vacuums and lenses, phase plates and ...
Tom Ceska +4 more
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Proteins: Structure, Function, and Bioinformatics, 2021 Abstract Structures of seven CASP14 targets were determined using cryo‐electron microscopy (cryo‐EM) technique with resolution between 2.1 and 3.8 Å. We provide an evaluation of the submitted models versus the experimental data (cryo‐EM density maps) and experimental reference structures built into the maps.
Tristan Cragnolini +2 more
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, 2021 (a) Data processing flow chart with particle distributions. The black box indicates the particle class used for further refinement. (b) Representative 2D classes. (c) FSC curves.
Christopher E. Morgan (11269227) +5 more
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IUCrJ, 2020 The application of cryo-EM methods to study SARS-CoV-2 proteins provides a convincing demonstration of the power of cryo-EM in the arsenal of structural biology.
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Frontiers in Molecular Biosciences, 2022 An increasing number of protein complex structures are determined by cryo-electron microscopy (cryo-EM). When individual protein structures have been determined and are available, an important task in structure modeling is to fit the individual ...
Eman Alnabati +4 more
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