Results 61 to 70 of about 6,328,527 (298)
, 2021 (a) Data processing flow chart with particle distributions. The black box indicates the particle class used for further refinement. (b) Representative 2D classes. (c) FSC curves.
Christopher E. Morgan (11269227) +5 more
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Nature CommunicationsUropathogenic Escherichia coli strains use filamentous type 1 pili to adhere to and invade uroepithelial cells. The pilus consists of a flexible tip fibrillum, formed by the adhesin FimH and the subunits FimG and FimF. The pilus rod is a helical assembly
Paul Bachmann +3 more
doaj +1 more source
Cryo-EM analysis of MmpL3-TMM III.
, 2021 (a) Data processing flow chart with particle distributions. The black box indicates the particle class used for further refinement. (b) Representative 2D classes. (c) FSC curves.
Christopher E. Morgan (11269227) +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Diverse Morphology and Structural Features of Old and New World Hantaviruses
Viruses, 2019 To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV ...
Amar Parvate +6 more
doaj +1 more source
Cryo-EM analysis of ΔN25 Spike complex.
, 2023 A. Flow chart of the cryo-EM data processing procedure. Details can be found in the Materials and methods. B. A representative cryo-EM micrograph. C. Angular orientation distribution of the particles used in the final reconstruction.
Jelle M. Melchers (15383558) +15 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules
IUCrJMolecular structures can be determined in vitro and in situ with cryo-electron microscopy (cryo-EM). Specimen preparation is a major obstacle in cryo-EM. Typical sample preparation is orders of magnitude slower than biological processes.
Alejandra Montaño Romero +2 more
doaj +1 more source
Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud
eLife, 2015 The advent of a new generation of electron microscopes and direct electron detectors has realized the potential of single particle cryo-electron microscopy (cryo-EM) as a technique to generate high-resolution structures.
Michael A Cianfrocco +1 more
doaj +1 more source