Results 231 to 240 of about 6,328,527 (298)

Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations. [PDF]

Nat Commun
Qoraj D, Mohr S, Aldakul YK, Sprink T, Öster C, Xiao T, Schmieder P, Lange S, Utesch T, Roderer D, Chen S, Sun H, Lange A.   +12 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Protein Engineering-Enabled Cryo-EM Investigation of Small GTPases. [PDF]

J Mol Biol
Hu Z, Patel UR, Glasser E, Koide A, Koide S.   +4 more
europepmc   +1 more source

Correlating Mid‐Infrared Absorption With Radiative Efficiency in Passive Daytime Radiative Cooling Systems

Macromolecular Rapid Communications, EarlyView.
We establish a correlation between the mid‐IR photonic response of Passive Daytime Radiative Cooling systems and their thermal radiation performances, characterized within a dedicated setup that simulates the irradiance toward outer space under controlled and reproducible conditions.
Emma Spotorno, Paola Stagnaro, Lucia Conzatti, Simona Losio, Roberto Utzeri, Francesco Bisio   +5 more
wiley   +1 more source

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline. [PDF]

Nat Commun
Stuart WS, Isupov MN, McLaren M, Jenkins CH, Monier A, Daum B, Norville IH, Gold VAM, Harmer NJ.   +8 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Cryo-EM structure of TGFBIp fibrils driven by a corneal dystrophy-linked mutation enables design of peptide inhibitors of aggregation. [PDF]

Proc Natl Acad Sci U S A
Jiang YX, Salwinski L, Sawaya MR, Ge P, Lutter L, Cheng X, Hu CJ, Hernandez H, Boyer DR, Wang C, Melo FA, Cascio D, Eisenberg DS.   +12 more
europepmc   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control. [PDF]

Nat Methods
Gemin O, Armijo V, Lecomte L, Hons M, Deckers T, Bissardon C, Rossi C, Lauzier K, Janocha R, Felisaz F, Sinoir J, Linares R, Babenko A, Kovalev K, Prokhorova I, Khusainov I, Schreiner C, Kolesnikova O, Salo VT, Schneider S, Bowler MW, Wolff G, Galej WP, Mahamid J, Müller CW, Carugo KD, Eustermann S, Mattei S, Cipriani F, Papp G.   +29 more
europepmc   +1 more source